6974-47-6

Basic information

• Product Name: 3-(1,3-benzodioxol-5-yl)methacrylaldehyde
• Synonyms: 3-(1,3-benzodioxol-5-yl)methacrylaldehyde;3-(1,3-Benzodioxole-5-yl)-2-methylpropenal;2-Methyl-3-(3,4-methylenedioxyphenyl)-2-propenal;2-Piperonylidenepropanal;2-Propenal, 3-(1,3-benzodioxol-5-yl)-2-methyl-;3-Piperonylidenepropanal;Nsc23870;Piperonylidene propionaldehyde
• CAS NO: 6974-47-6
• Molecular Formula: C₁₁H₁₀O₃
• Molecular Weight: 190.1953
• EINECS: 230-222-5
• Mol File: 6974-47-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 328.6°C at 760 mmHg
• Flash Point: 143.6°C
• Appearance: /
• Density: 1.225g/cm³
• Vapor Pressure: 0.000187mmHg at 25°C
• Refractive Index: 1.598
• CAS DataBase Reference: 3-(1,3-benzodioxol-5-yl)methacrylaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1,3-benzodioxol-5-yl)methacrylaldehyde(6974-47-6)
• EPA Substance Registry System: 3-(1,3-benzodioxol-5-yl)methacrylaldehyde(6974-47-6)

Safety Data

• Hazardous Substances Data: 6974-47-6(Hazardous Substances Data)

Usage

General Description

3-(1,3-benzodioxol-5-yl)methacrylaldehyde is a chemical compound with the molecular formula C11H8O3. It is a yellow crystalline solid that is used in the synthesis of organic compounds and as a reagent in chemical reactions. 3-(1,3-benzodioxol-5-yl)methacrylaldehyde is derived from the reaction of 3-(1,3-benzodioxol-5-yl)propanoic acid with an oxidizing agent to form the corresponding aldehyde group. It is also used as a precursor in the production of various pharmaceuticals and agrochemicals. The compound is known for its ability to undergo polymerization reactions, making it useful in the production of polymers and plastics. Additionally, 3-(1,3-benzodioxol-5-yl)methacrylaldehyde is used as a building block in the synthesis of fragrances, flavors, and other fine chemicals.

InChI:InChI=1/C11H10O3/c1-8(6-12)4-9-2-3-10-11(5-9)14-7-13-10/h2-6H,7H2,1H3/b8-4+

Upstream product

• 120-57-0 piperonal 
• 123-38-6 propionaldehyde 
• 68-12-2 N,N-dimethyl-formamide 
• 120-58-1 isosafrole 
• 10025-87-3 trichlorophosphate 
• 89424-83-9 1,3-dihydroisobenzofuran-5-carbaldehyde 
• 6890-30-8 1-piperonyl-1-propanol 
• 119346-68-8 ethyl 3-(benzo[d][1,3]dioxol-6-yl)-2-methyl-2-propenoate 
• 1205-17-0 helional 

Downstream Products

• 1446-84-0 2-methyl-3-(3,4-methylenedioxyphenyl)-1-propanol 
• 1205-17-0 helional 

Relevant articles and documents

An efficient Pd@Pro-GO heterogeneous catalyst for the α, β-dehydrogenation of saturated aldehyde and ketones

An Efficient Pd@Pro-GO heterogeneous catalyst was developed that can promote the α, β-dehydrogenation of saturated aldehyde and ketones in the yield of 73% ? 92% at mild conditions without extra oxidants and additives. Pd@Pro-GO heterogeneous catalyst was synthesized via two steps: firstly, the Pro-GO was obtained by the esterification reaction between graphene oxide (GO) and N-(tert-Butoxycarbonyl)-L-proline (Boc-Pro-OH), followed by removing the protection group tert-Butoxycarbonyl (Boc), which endowed the proline-functionalized GO with both the lewis acid site (COOH) and the bronsted base site (NH), besides, the pyrrolidine of proline also can form imine with aldehydes to activate these substrates; Second, palladium was dispersed on the proline-functionalized GO (Pro-GO) to obtained heterogeneous catalyst Pd@Pro-GO. Mechanistic studies have shown that the Pd@Pro-GO-catalyzed α,β-dehydrogenation of saturated aldehyde and ketones was realized by an improved heterogeneously catalyzed Saegusa oxidation reaction. Based on the obove characteristics, the Pd@Pro-GO will be widely used in the transition metal catalytic field.

The present invention relates to a new process for the preparation of heliotropine

The invention relates to a method for preparing helional and discloses a method which comprises steps of carrying out Claisen-Schmidt condensation reaction between heliotropin serving as a raw material and propionaldehyde under the catalysis of strong-basicity ion exchange resin, and further performing catalytic hydrogenation so as to obtain the target product. The method is characterized in that the strong-basicity ion exchange resin is used to replace other strong bases for catalyzing Claisen-Schmidt condensation reaction, the reaction yield is greatly improved, disproportionation reaction which can cause relevant impurities is avoided, and the purification is easy. The method is a route which is high in yield, low in cost, safe and applicable for industrial synthesis.

An organocatalytic asymmetric nazarov cyclization

An organocatalytic asymmetric Nazarov cyclization of diketoesters that proceeds by means of a dual activation mechanism has been developed. Screening of a number of catalysts led to a new thiourea that incorporates a primary amino group. The method gives rise to cyclic products with two adjacent quaternary asymmetric carbon atoms, one of which is an all-carbon stereocenter, with complete or nearly complete diastereoselectivity and in high or very high enantiomeric excess. A brief and very convenient synthesis of the acyclic diketoester starting materials through nucleophilic addition to a ketene is also described.