6975-73-1

Basic information

• Product Name: diazenyl-(1-hydroxypyridin-4-ylidene)methanol
• Synonyms: diazenyl-(1-hydroxypyridin-4-ylidene)methanol;4-Pyridinecarboxylic acid, hydrazide, 1-oxide ;4-(HYDRAZINECARBONYL)PYRIDIN-1-IUM-1-OLATE;Topiroxostat impurity E;Topiroxostat Impurity I2;4-(hydrazinecarbonyl)pyridine 1-oxide
• CAS NO: 6975-73-1
• Molecular Formula: C₆H₇N₃O₂
• Molecular Weight: 153.14
• Mol File: 6975-73-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 212-213 °C(Solv: ethanol, 85% (64-17-5))
• Boiling Point: 208.9°Cat760mmHg
• Flash Point: 80.1°C
• Appearance: /
• Density: 1.42g/cm³
• Vapor Pressure: 0.0482mmHg at 25°C
• Refractive Index: 1.631
• PKA: 11.71±0.10(Predicted)
• CAS DataBase Reference: diazenyl-(1-hydroxypyridin-4-ylidene)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: diazenyl-(1-hydroxypyridin-4-ylidene)methanol(6975-73-1)
• EPA Substance Registry System: diazenyl-(1-hydroxypyridin-4-ylidene)methanol(6975-73-1)

Safety Data

• Hazardous Substances Data: 6975-73-1(Hazardous Substances Data)

Usage

Description

Diazenyl-(1-hydroxypyridin-4-ylidene)methanol is a chemical compound with the potential for various applications in the pharmaceutical industry. It is characterized by its unique molecular structure, which includes a diazenyl group and a hydroxypyridin-4-ylidene moiety, attached to a methanol group. diazenyl-(1-hydroxypyridin-4-ylidene)methanol is known for its reactivity and versatility in chemical synthesis, particularly in the preparation of pharmaceutical compounds.

Uses

Used in Pharmaceutical Synthesis:
Diazenyl-(1-hydroxypyridin-4-ylidene)methanol is used as a reagent in the preparation of anti-tuberculosis compounds. Its unique chemical structure allows for the synthesis of novel molecules with potential therapeutic properties against tuberculosis, a disease that continues to be a significant global health concern.
In the pharmaceutical industry, diazenyl-(1-hydroxypyridin-4-ylidene)methanol is used as a key intermediate in the synthesis of various drugs, particularly those targeting tuberculosis. Its application in this field is due to its ability to facilitate the formation of new chemical entities with improved efficacy and reduced side effects compared to existing treatments.
Additionally, the compound's reactivity and structural diversity make it a valuable tool in the development of other therapeutic agents, potentially expanding its applications beyond tuberculosis to include other diseases and conditions. Further research and development are necessary to fully explore and understand the compound's potential in various pharmaceutical applications.

InChI:InChI=1/C6H7N3O2/c7-8-6(10)5-1-3-9(11)4-2-5/h1-4,7,10-11H/b8-7+

Upstream product

• 14906-37-7 ethyl isonicotinate N-oxide 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 1570-45-2 isonicotinic acid ethylester 
• 3783-38-8 methyl isonicotinate N-oxide 

Downstream Products

• 109941-24-4 1-(1-oxy-isonicotinoyl)-4-phenyl thiosemicarbazide 
• 100868-12-0 1-oxy-isonicotinic acid vanillylidenehydrazide 
• 1453-82-3 isonicotinamide 
• 837371-89-8 5-(1-oxy-pyridin-4-yl)-3-[3-cyano-4-{2-(2-methoxyethoxy)ethoxy}phenyl]-1,2,4-triazole 
• 36770-53-3 4-[5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl]-pyridine-N-oxide 

Relevant articles and documents

Intermediate for topipitastat, preparation method thereof, and method for preparing topipitastat from intermediate

The invention belongs to the technical field of medicines, and particularly relates to an intermediate for topipitastat, a preparation method thereof, and a method for preparing topipitastat from theintermediate. The intermediate for the topipitastat is 3-(4-pyridyl)-5-(1-oxo-4-pyridyl)-1,2,4-triazole p-toluenesulfonate, and the structural formula of the intermediate is represented by formula (I). The preparation methods are characterized in that methyl isonicotinate oxynitride and hydrazine hydrate undergo a condensation reaction, a ring closing reaction and a salt formation reaction to obtain the intermediate, and the intermediate and N,N-dimethylformyl chloride undergo a cyanation reaction and a refining reaction to obtain the topipitastat. The methods effectively solve the technical problems of complex preparation process and low purity of topiroxostat, and have the advantages of simple process, good reproducibility, low cost, environmental protection and energy saving, so the methods have high industrial values and remarkable social and economic benefits. The preparation methods are used for preparing the key intermediate for the topiroxostat and the topiroxostat.

A method for synthesizing holds the pyrrole department he (by machine translation)

The present invention provides a method for the synthesis of I he holds the pyrrole department, comprising the following steps: 1), II to isonicotinic acid methyl ester as the raw material, the presence of the oxidizing agent, is generated by the oxidation of isonicotinic acid methyl ester N-oxide III; 2), then condensation with hydrazine hydrate to obtain retozide N-oxide IV; 3), compound IV with 4-cyanopyridine mellow alkali V under the conditions of the reaction to produce 4 - (2 - (imino (pyridin-4-yl) methyl) [...] ) pyridine N-oxide VI; 4), the presence of the dimethyl carbamic chloride, and cyanide reaction to produce 2-cyano-Nˊ - (imino (pyridin-4-yl) methyl) retozide VII; 5), the resulting compound in the presence of an acid VII to cyclization, I have he holds the pyrrole department ; the reaction route is as follows: In the method of the invention, the total yield, on the one hand relative to the literature yield greatly improved, on the other hand, line is simple and easy to obtain the raw materials and low cost, the steps of the mild reaction conditions, the post-processing is simple; it is very easy to be industrialized control. (by machine translation)