69759-61-1 Usage
Description
2,7-Dichloro-alpha-[(dibutylamino)methyl]-9H-fluorene-4-methanol is a pale yellow solid that is an impurity formed during the synthesis of Lumefantrine (L474000), a fluorene (F462000) derivative belonging to the aryl amino alcohol class of anti-malarial drugs.
Uses
Used in Pharmaceutical Industry:
2,7-Dichloro-alpha-[(dibutylamino)methyl]-9H-fluorene-4-methanol is used as an impurity in the synthesis of Lumefantrine, an anti-malarial drug. Its presence is significant as it is a byproduct of the synthesis process, and its management is crucial for ensuring the purity and efficacy of the final drug product.
As an impurity in the synthesis of Lumefantrine, it is important to monitor and control the levels of 2,7-Dichloro-alpha-[(dibutylamino)methyl]-9H-fluorene-4-methanol to maintain the safety and effectiveness of the anti-malarial medication. This may involve developing and implementing purification techniques or adjusting the synthesis process to minimize the formation of this impurity.
Check Digit Verification of cas no
The CAS Registry Mumber 69759-61-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,9,7,5 and 9 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 69759-61:
(7*6)+(6*9)+(5*7)+(4*5)+(3*9)+(2*6)+(1*1)=191
191 % 10 = 1
So 69759-61-1 is a valid CAS Registry Number.
69759-61-1Relevant articles and documents
Preparation method for benflumetol and matched system thereof
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, (2020/05/02)
The invention belongs to the field of benflumetol, and relates to preparation and a system for the benflumetol, in particular to a preparation method for the benflumetol and a matched system thereof.The preparation method for the benflumetol is completed by sequentially through bulk drugs, a plurality of intermediates and the benflumetol. The matched system for the preparation method sequentiallycomprises an intermediate I matched system, an intermediate II matched system, an intermediate IV matched system, an intermediate V matched system and a benflumetol matched system. According to the invention, overall preparation is simple, reasonable and highly-efficient; the required time is greatly shortened; and exploration of industrial production conditions of the benflumetol is completed.
Antimalarials. 3. Fluorenemethanols
Atkinson,Granchelli
, p. 1009 - 1012 (2007/10/06)
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