69770-99-6

Basic information

• Product Name: N-(tert-butyl)-2-(4-chlorophenyl)-2-oxoacetamide
• Synonyms: N-(tert-butyl)-2-(4-chlorophenyl)-2-oxoacetamide
• CAS NO: 69770-99-6
• Molecular Weight: 239.702
• Mol File: 69770-99-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: N-(tert-butyl)-2-(4-chlorophenyl)-2-oxoacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(tert-butyl)-2-(4-chlorophenyl)-2-oxoacetamide(69770-99-6)
• EPA Substance Registry System: N-(tert-butyl)-2-(4-chlorophenyl)-2-oxoacetamide(69770-99-6)

Safety Data

• Hazardous Substances Data: 69770-99-6(Hazardous Substances Data)

Upstream product

• 601468-08-0 N?(tert?butyl)?2?(4?chlorophenyl)imidazo[1,2?a]pyridin?3?amine 
• 637-87-6 1-Chloro-4-iodobenzene 
• 201230-82-2 carbon monoxide 
• 75-64-9 tert-butylamine 
• 82102-37-2 9-methyl-9H-fluorene-9-carbonyl chloride 
• 119072-55-8 tert-butylisonitrile 
• 104-88-1 4-chlorobenzaldehyde 
• 854247-96-4 N-tert-butyl-2-(4-chlorophenyl)-8-methylimidazo[1,2-a]pyridin-3-amine 

Relevant articles and documents

Diverse Oxidative C(sp2)-N Bond Cleavages of Aromatic Fused Imidazoles for Synthesis of α-Ketoamides and N-(pyridin-2-yl)arylamides

An efficient and chemoselective C(sp2)-N bond cleavage of aromatic imidazo[1,2-a]pyridine molecules is developed. A broad scope of amide compounds such as α-ketoamides and N-(pyridin-2-yl)arylamides are afforded as the final products in up to quantitative yields. Diverse C-N bond cleavages are controlled by the oxidative species used in this transformation, with various amide products afforded in a chemoselective fashion. A preliminary study indicated that some α-ketoamides exhibit anti-Tobacco Mosaic Virus activity for potential use in plant protection.

A catalytic method for synthesizing α - one amide compound

The invention discloses a catalytic carbonylation method for synthesis of alpha-keto amide. A palladium source in an aqueous solution of polyethylene glycol or polyethylene glycol is used for in-situ formation of a highly active palladium nano-catalyst; a

Substituent effects in aminocarbonylation of para-substituted iodobenzenes

Iodobenzene derivatives possessing various substituents (amino, hydroxy, tert-butyl, methyl, isopropyl, phenyl, fluoro, chloro, methoxycarbonyl, acetyl, trifluoromethyl, nitro) in the para position were aminocarbonylated using tert-butylamine and n-butylamine as N-nucleophiles. A palladium(0) catalyst formed in situ from palladium(II) acetate and triphenylphosphine was used. Carboxamide and ketocarboxamide type compounds were formed via single and double carbon monoxide insertion, respectively. While 4-substituents with negative Hammett constants (σp) decrease reactivity of the substrates, the iodoaromatics possessing electron-withdrawing group (characterized by positive Hammett constants (σp)) in the 4-position have shown high reactivity. Highly active catalysts were obtained in the presence of xantphos accompanied by the chemoselective formation of the corresponding carboxamides. The difference in reactivity of iodoarene and bromoarene functionalities enabled the synthesis of bromo-substituted compounds suitable for further functionalization.