697762-63-3Relevant articles and documents
egypt for pulls Wei intermediate and its preparation method and application
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, (2016/12/01)
The invention discloses an elvitegravir intermediate and a preparation method and application thereof. The elvitegravir intermediate has a chemical structure shown as FORMULA II, in which X is Cl, Br or I, and a chemical structure shown as FORMULA III. Application of the elvitegravir intermediate to synthesis of elvitegravir has the advantages as follows: simple preparation process, mild reaction conditions, cheap and easily-available raw materials, high total molar yield, simple posttreatment, high product purity and the like, is very suitable for large-scale production and has a great significance and a practical value for low-cost and large-scale preparation of high-purity elvitegravir.