69790-73-4Relevant articles and documents
Gram-Scale Laboratory Synthesis of UM171, a Potent Agonist of Human Hematopoietic Stem Cell Self-Renewal
Ali, Sajjad,Yu, Shun-Ming,Yao, Zhu-Jun
, p. 10236 - 10241 (2016)
A short economic synthesis of pyrimidoindole derivative UM171, a potent agonist for the ex vivo expansion of hematopoietic stem cells, has been developed in this work. A unique [3,3]-sigmatropic rearrangement upon a hydroxamic precursor followed by base-promoted cyclization was successfully applied as the key step, furnishing the fully functionalized indole nucleus. The current synthesis is not only capable of affording UM171 in gram quantities but also offers great flexibility in late-stage diversification. Three new analogues of UM171 were synthesized accordingly in excellent yields using the common indole-carboxamide intermediate.
Antitumor effect of 2, 4, 7-trisubstituted pyrimidino indole compound
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, (2021/05/29)
The invention relates to a series of compounds with 2, 4, 7-trisubstituted pyrimidino indole structures, and the compounds can inhibit the growth of various tumor cells, and particularly, the compounds can efficiently inhibit the proliferation of breast cancer, cervical cancer, gastric adenocarcinoma and liver cancer cells. In addition, the compound can inhibit tumor cell clone formation at a very low concentration and promote tumor cell apoptosis. The invention also relates to a preparation method of the compound and application of the compound in marking, diagnosis, prevention and treatment or adjuvant therapy of tumors.
Novel tetrazole-oriented meta-position nitration C-H activation method
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Paragraph 0011, (2020/02/14)
The invention provides a novel tetrazole-oriented meta-position-selective C-H nitration method. The method comprises the following steps: by taking a 5-phenyl tetrazole compound as a raw material, carrying out meta-position nitration catalyzed by transiti
