69808-71-5Relevant articles and documents
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Pigulla,Roeder
, p. 12,15 (1979)
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Cu(OAc)2-Promoted Oxidative Cross-Dehydrogenative Coupling Reaction of α-Acylmethyl Malonates with Indole Derivatives to Access 3-Functionalized Indoles and Polycyclic Indoles
Zhou, Li-Jin,Wang, Kun,Guan, Hong-Rong,Zheng, An-Qi,Yang, Hai-Tao,Miao, Chun-Bao
, p. 7925 - 7938 (2020/07/25)
A Cu(OAc)2-promoted oxidative cross-dehydrogenative coupling reaction of α-acylmethyl malonates with indole derivatives was developed. In the case of indoles, the regioselective coupling products were formed through a sequential dehydrogenation-addition-dehydrogenation process. When a second nucleophilic center was located in the 2-position of indoles, further successive nucleophilic cyclization occurred to give polycyclic indole derivatives. The Cu(OAc)2 was proved to act as not only an oxidant but also a catalyst.
Total synthesis and structural revision of a mangrove alkaloid
Green, Michael T.,Peczkowski, Gary R.,Al-Ani, Aneesa J.,Benjamin, Sophie L.,Simpkins, Nigel S.,Jones, Alan M.
, p. 48754 - 48758 (2017/11/06)
We report the total synthesis of an alkaloid isolated from the mangrove fungi Hypocrea virens, based on the originally claimed structure, via a photochemical sequence. Inconsistencies between data sets led to a revision of the proposed structure followed by a concise synthetic sequence to deliver the revised natural product.
Synthesis of heteroarylogous 1H-indole-3-carboxamidines via a three-component interrupted Ugi reaction
La Spisa, Fabio,Meneghetti, Fiorella,Pozzi, Beatrice,Tron, Gian Cesare
, p. 489 - 496 (2015/02/19)
A novel one-pot multicomponent synthesis of heteroarylogous 1H-indole-3-carboxamidines starting from readily available N-alkyl-N-(1H-indol-2-ylmethyl)amines, isocyanides, and carbonyl compounds is reported. The strategy exploits the ability of the indole nucleus to interrupt the classical Ugi reaction, by intercepting the nascent nitrilium ion.
