698351-27-8

Basic information

• Product Name: 2-(N-tert-butoxycarbonyl-N-methylamino)-1-phenyl-1-butanone
• Synonyms: 2-(N-tert-butoxycarbonyl-N-methylamino)-1-phenyl-1-butanone
• CAS NO: 698351-27-8
• Molecular Weight: 277.364
• Mol File: 698351-27-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(N-tert-butoxycarbonyl-N-methylamino)-1-phenyl-1-butanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(N-tert-butoxycarbonyl-N-methylamino)-1-phenyl-1-butanone(698351-27-8)
• EPA Substance Registry System: 2-(N-tert-butoxycarbonyl-N-methylamino)-1-phenyl-1-butanone(698351-27-8)

Safety Data

• Hazardous Substances Data: 698351-27-8(Hazardous Substances Data)

Upstream product

• 140150-48-7 Methyl-(1-tributylstannanyl-propyl)-carbamic acid tert-butyl ester 
• 611-74-5 N,N-dimethylbenzamide 

Downstream Products

• 63199-79-1 2-(N-methylamino)-1-phenyl-1-butanol 
• 408332-79-6 2-(N-methylamino)-1-phenyl-1-butanone 
• 63199-79-1 2-(N-methylamino)-1-phenyl-1-butanol 

Relevant articles and documents

Diastereoselective reduction of α-aminoketones: Synthesis of anti- and syn-β-aminoalcohols

Reduction of N-t-BOC-protected-N-alkyl α-aminoketones with LiEt 3BH or Li(S-Bu)3BH furnishes protected syn-β-aminoalcohols with high selectivities. In contrast, removal of the BOC group followed by reduction of the aminoketone gives anti-β- aminoalcohols with variable selectivities. With aromatic ketones, selectivities are typically high while aliphatic ketones show mediocre to high selectivities depending on steric considerations.