69872-64-6

Basic information

• Product Name: Alanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosyl]-2-methyl-, methyl ester
• CAS NO: 69872-64-6
• Molecular Formula: C19H28N2O6
• Molecular Weight: 380.441
• Mol File: 69872-64-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Alanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosyl]-2-methyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Alanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosyl]-2-methyl-, methyl ester(69872-64-6)
• EPA Substance Registry System: Alanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosyl]-2-methyl-, methyl ester(69872-64-6)

Safety Data

• Hazardous Substances Data: 69872-64-6(Hazardous Substances Data)

Upstream product

• 3978-80-1 Boc-Tyr-OH 
• 15028-41-8 methyl 2-aminoisobutyrate hydrochloride 
• 60-18-4 L-tyrosine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 13257-67-5 2-amino-2-methylpropionic acid methyl ester 

Downstream Products

• 69872-65-7 N-(tert-butoxycarbonyl)-L-tyrosyl-α-aminoisobutyric acid 
• 1269631-90-4 Boc-Tyr-Aib-Leu-OMe 
• 1269631-91-5 Boc-Tyr-Aib-Ileu-OMe 
• 112550-26-2 N-(tert-butoxycarbonyl)-L-tyrosyl-α-aminoisobutyrylglicine methyl estere 

Relevant articles and documents

Practical Peptide Synthesis Mediated by a Recyclable Hypervalent Iodine Reagent and Tris(4-methoxyphenyl)phosphine

6-(3,5-Bis(trifluoromethyl)phenyl)-1H,4H-2aλ3-ioda-2,3-dioxacyclopenta[hi]indene-1,4-dione (p-BTFP-iodosodilactone, 1a) was synthesized and demonstrated to be an efficient hypervalent iodine(III) reagent for the synthesis of dipeptides from various standard amino acids, including sterically hindered amino acids, in good to high yields within 30 min in the presence of tris(4-methoxyphenyl)phosphine. In addition, the combined system of 1a/(4-MeOC6H4)3P was used to synthesize the pentapeptide leu-enkephalin in protected form. It is worth noting that 1a can be regenerated readily after reaction.

Insights into self-assembling nanoporous peptide and in situ reducing agent

A tripeptide containing an Aib (α-amino isobutyric acid) residue self-assembles to form porous nanomaterials in solid state. In spite of having a hollow nanotubular structure, the self-assembly nature of the peptide is different, which leads to the formation of pores with different internal diameters. The single-crystal X-ray diffraction study reveals that the peptide forms continuous hydrogen-bonded poly-disperse nanopores (3, 5 and 8 membered) starting from the β-turn conformation as an associating sub-unit. The field emission scanning electron micrograph (FESEM) shows that the average pore sizes are in the range of 20 to 200 nm, although a few large pores are also visible. Moreover, the peptide 1 acts as an in situ reducing agent to synthesize hexagonal gold nanoparticles (GNP).

Investigation of the structural parameters involved in the μ and δ opioid receptor discrimination of linear enkephalin-related peptides

The previous rules proposed for selective recognition of μ and δ opioid receptors by modified enkephalins were investigated through an extensive structure-activity study. Thus, modifications of the sequence of TRIMU 4 (Tyr-D-Ala-Gly-NHCH(CH3)CH