69873-67-2

Basic information

• Product Name: Benzoic acid, 2-[(2-pyridinylcarbonyl)amino]-, methyl ester
• CAS NO: 69873-67-2
• Molecular Formula: C14H12N2O3
• Molecular Weight: 256.261
• Mol File: 69873-67-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-[(2-pyridinylcarbonyl)amino]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-[(2-pyridinylcarbonyl)amino]-, methyl ester(69873-67-2)
• EPA Substance Registry System: Benzoic acid, 2-[(2-pyridinylcarbonyl)amino]-, methyl ester(69873-67-2)

Safety Data

• Hazardous Substances Data: 69873-67-2(Hazardous Substances Data)

Upstream product

• 29745-44-6 pyridine-2-carbonyl chloride 
• 134-20-3 2-carbomethoxyaniline 
• 98-98-6 2-Picolinic acid 

Downstream Products

• 58668-43-2 N-(2-carboxyphenyl)pyridine-2'-carboxamide 
• 1072106-84-3 C₁₄H₁₁ClN₂O₂ 
• 68870-65-5 pyridine-2-carboxylic acid(2-formyl-phenyl)-amide 

Relevant articles and documents

Exploring the dual inhibitory activity of novel anthranilic acid derivatives towards α-glucosidase and glycogen phosphorylase antidiabetic targets: Design, in vitro enzyme assay, and docking studies

A few new anthranilate diamide derivatives, 3a–e, 5a–c and 7a–d, were designed, synthesized, and evaluated for their inhibitory activity against two interesting antidiabetic targets, α-glucosidase and glycogen phosphorylase enzymes. Different instrumental analytical tools were applied in identification and conformation of their structures like;13C NMR,1H NMR and elemental analysis. The screening of the novel compounds showed potent inhibitory activity with nanomolar concentration values. The most active compounds (5c) and (7b) showed the highest inhibitory activity against α-glucosidase and glycogen phosphorylase enzymes IC50 = 0.01247 ± 0.01 μM and IC50 = 0.01372 ± 0.03 μM, respectively. In addition, in vivo testing of the highly potent α-glucosidase inhibitor (7b) on rats with DTZ-induced diabetes was done and showed significant reduction of blood glucose levels compared to the reference drug. Furthermore, a molecular docking study was performed to help understand the binding interactions of the most active analogs with these two enzymes. The data obtained from the molecular modeling were correlated with those obtained from the biological screening. These data showed considerable antidiabetic activity for these newly synthesized compounds.

An efficient synthesis of 2,3-diaryl (3H)-quinazolin-4-ones via imidoyl chlorides

A practical and efficient three step synthetic route to 2,3-diaryl (3H)-quinazolin-4-ones has been developed. The key step involves microwave-assisted condensation of an imidoyl chloride with an aryl amine. This methodology affords the products cleanly and in high yields.

Fungicidal activity of N-benzoylanthranilates and related compounds

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