69898-45-9

Basic information

• Product Name: Sodium 3-(pyridin-2-yl)-1,2,4-triazine-5,6-diyl]bis(benzene-4,4'-sulphonate) hydrate
• Synonyms: 4,4'-[3-(2-Pyridinyl)-1,2,4-triazine-5,6-diyl]bis(benzenesulfonic acid)1-sodium salt;Ferrozine (3-(2-Pyridyl)-5,6-bis(4-phenylsulfonic acid)-1,2,4-tr;Einecs 274-196-3;BENZENESULFONIC ACID, 4,4'-[3-(2-PYRIDNYL)-1,2,4-TRIAZINE-5,6-DIYL]BIS-;Sodium 3-(pyridin-2-;Ferrozine(R) analytical grade;Phenanthroline hydrochloride;5,6-Diphenyl-3-(2-pyridyl)-1,2,4-triazine-4,4"-disulfonicacidmonosodiumsalthydrate,97%
• CAS NO: 69898-45-9
• Molecular Formula: C₂₀H₁₃N₄O₆S₂*Na
• Molecular Weight: 492.46
• EINECS: 248-797-6
• Mol File: 69898-45-9.mol
• Article Data: 0

Chemical Properties

• Melting Point: ≥300 °C
• Appearance: /
• Storage Temp.: Store at RT.
• Solubility: H2O: soluble50mg/mL
• Water Solubility: Soluble in water (partly).
• BRN: 5222087
• CAS DataBase Reference: Sodium 3-(pyridin-2-yl)-1,2,4-triazine-5,6-diyl]bis(benzene-4,4'-sulphonate) hydrate(CAS DataBase Reference)
• NIST Chemistry Reference: Sodium 3-(pyridin-2-yl)-1,2,4-triazine-5,6-diyl]bis(benzene-4,4'-sulphonate) hydrate(69898-45-9)
• EPA Substance Registry System: Sodium 3-(pyridin-2-yl)-1,2,4-triazine-5,6-diyl]bis(benzene-4,4'-sulphonate) hydrate(69898-45-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-36
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 69898-45-9(Hazardous Substances Data)

Usage

Description

Sodium 3-(pyridin-2-yl)-1,2,4-triazine-5,6-diyl]bis(benzene-4,4'-sulphonate) hydrate, also known as Ferrozine sodium salt or simply Ferrozine, is an organic sodium salt that serves as an iron chelator. It is the monosodium salt of 4,4'-[3-(pyridin-2-yl)-1,2,4-triazine-5,6-diyl]dibenzenesulfonic acid and contains a ferrozine(2-). Ferrozine is characterized by its yellow to yellow-green powder form and is soluble in water. It plays a significant role in the detection and removal of iron ions, particularly in the context of reactive oxygen species (ROS) identification.

Uses

1. Used in Chemical Analysis:
Ferrozine is employed as a reagent and indicator for iron, forming a stable magenta-colored solution with the ferrous ion. The complex has an absorption peak at 562 nm, making it a valuable tool in the detection and quantification of iron in various samples.
2. Used in Removal of Iron from Physiological Fluids and Tissue Samples:
Ferrozine is used for the removal of iron from physiological fluids and tissue samples to identify the presence of reactive oxygen species (ROS). It binds to iron ions and forms ferrous complexes that are excreted through urine or bile, thus facilitating the analysis of ROS.
3. Used in Inhibition of Lipid Peroxidation:
Ferrozine has been shown to inhibit lipid peroxidation in rat liver mitochondria. This may be attributed to its ability to react with hydrogen peroxide and form a complex with iron-hydrogen peroxide, which prevents the formation of hydroxyl radicals, ultimately protecting the cell from oxidative damage.
4. Used in Heavy Metal Determination:
As an organic ligand, Ferrozine is useful as a disposable optical sensor for heavy metal determination. Its chelation properties allow for the detection and measurement of heavy metals in various environmental and industrial applications.