699001-67-7Relevant articles and documents
Biaryl amide glucagon receptor antagonists
Kurukulasuriya, Ravi,Sorensen, Bryan K.,Link, James T.,Patel, Jyoti R.,Jae, Hwan-Soo,Winn, Marty X.,Rohde, Jeffrey R.,Grihalde, Nelson D.,Lin, Chun W.,Ogiela, Christopher A.,Adler, Andrew L.,Collins, Christine A.
, p. 2047 - 2050 (2007/10/03)
Biaryl amides derived from a reported series of ureas 1 were evaluated and found to be potent human glucagon receptor antagonists. The benzofuran analogue 6i was administered in Sprague-Dawley rats and blocked the effects of an exogenous glucagon challenge.