699011-58-0Relevant articles and documents
An expedient total synthesis of triciribine
Hu, Chen,Ruan, Zhizhong,Ding, Haixin,Zhou, Yirong,Xiao, Qiang
, (2017/06/08)
In the present paper, we report an expedient total synthesis of triciribine, a tricyclic 7-deazapurine nucleoside and protein kinase B (AKT) inhibitor, in 35% overall yield. Our synthesis route features a highly regioselective substitution of 1-N-Boc-2-methylhydrazine and a trifluoroacetic acid catalyzed one-pot transformation which combined the deprotection of the tert-butylcarbonyl (Boc) group and ring closure reaction together to give a tricyclic nucleobase motif.