69967-78-8

Basic information

• Product Name: Benzene,1-(1,2-diphenyl-1-buten-1-yl)-4-methoxy-
• Synonyms: Anisole,p-(1,2-diphenyl-1-butenyl)- (7CI); Benzene,1-(1,2-diphenyl-1-butenyl)-4-methoxy- (9CI); 1-(4-Methoxyphenyl)-1,2-diphenyl-1-butene;ICI 90069
• CAS NO: 69967-78-8
• Molecular Formula: C23H22 O
• Molecular Weight: 314.427
• Mol File: 69967-78-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzene,1-(1,2-diphenyl-1-buten-1-yl)-4-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene,1-(1,2-diphenyl-1-buten-1-yl)-4-methoxy-(69967-78-8)
• EPA Substance Registry System: Benzene,1-(1,2-diphenyl-1-buten-1-yl)-4-methoxy-(69967-78-8)

Safety Data

• Hazardous Substances Data: 69967-78-8(Hazardous Substances Data)

Upstream product

• 108-86-1 bromobenzene 
• 78423-10-6 1-(4-methoxyphenyl)-2-phenylbutan-1-one 
• 611-94-9 4-Methoxybenzophenone 
• 93-55-0 1-phenyl-propan-1-one 
• 650624-48-9 4-(4-methoxyphenyl)-3,4-diphenylbut-1-ene 
• 857085-82-6 1-((Z)-1,2-Diphenyl-buta-1,3-dienyl)-4-methoxy-benzene 
• 591-50-4 iodobenzene 
• 846541-57-9 3t-(4-methoxy-phenyl)-2,3c-diphenyl-acrylic acid 
• 857906-52-6 1,2-diphenyl-2-(4-methoxyphenyl)vinyl bromide 
• 100-66-3 methoxybenzene 
• 90-27-7 2-Phenylbutyric acid 
• 109640-28-0 1,2-diphenyl-1-(p-methoxyphenyl)butan-1-ol 

Downstream Products

• 69967-80-2 1-phenyl-1-(p-hydroxyphenyl)-2-phenylbut-1-ene 
• 69967-79-9 ICI 77949 
• 68684-63-9 1-(4-hydroxyphenyl)-1,2-diphenylbut-1-ene 
• 10540-29-1 tamoxifen 
• 13002-65-8 (E)-tamoxifen 
• 31750-47-7 N-demethyltamoxifen 
• 97818-83-2 (Z)-1-<4-(2-chloroethoxy)phenyl>-1,2-diphenyl-1-butene 
• 97818-84-3 (E)-1-<4-(2-chloroethoxy)phenyl>-1,2-diphenyl-1-butene 
• 97818-91-2 (Z)-1-<4-<2-(diethylamino)ethoxy>phenyl>-1,2-diphenyl-1-butene 
• 97818-94-5 Z-2-<4-(1,2-diphenyl-1-butenyl)phenoxy>acetyl chloride 
• 97818-93-4 Z-2-<4-(1,2-diphenyl-1-butenyl)phenoxy>acetic acid 
• 97818-92-3 Z-ethyl 2-<4-(1,2-diphenyl-1-butenyl)phenoxy>acetate 
• 97818-85-4 Z-1,2-diphenyl-1-<4-(2-piperazinoethoxy)phenyl>-1-butene 

Relevant articles and documents

Synthesis of Highly Stereodefined Tetrasubstituted Acyclic All-Carbon Olefins via a Syn-Elimination Approach

An efficient synthesis of stereodefined tetrasubstituted acyclic all-carbon olefins has been developed via a bis(2,6-xylyl)phosphate formation of stereoenriched tertiary alcohols, followed by in situ syn-elimination of the corresponding phosphates under mild conditions. This chemistry tolerates a wide variety of electronically and sterically diverse substrates and generates the desired tetrasubstituted olefins in high yields and stereoselectivities (>95:5) in most cases. This stereocontrolled olefin synthesis has been applied to the synthesis of anticancer drug tamoxifen in three steps from commercially available 1,2-diphenylbutan-1-one in 97:3 stereoselectivity and 78% overall yield.

Intramolecularly activated vinylsilanes: Fluoride-free cross-coupling of (Z)-β-(trialkylsilyl)acrylic acids

The fluoride-free palladium-catalyzed cross-coupling reaction of trialkyl(vinyl)silanes activated by the intramolecular pentacoordination of carboxylic acid at the Z-β-position is described.

Short-step synthesis of tamoxifen and its derivatives via the three-component coupling reaction and migration of the double bond

The anti-tumor agent, tamoxifen, is easily synthesized by the successive allylation of benzaldehyde and the Friedel-Crafts alkylation reaction of anisole with the intermediary homoallyl silyl ethers, followed by the migration of the double bond to form the desired tetra-substituted ethylenes. Several derivatives of tamoxifen are also produced according to a similar synthetic strategy.