70-07-5 Usage
Originator
Trepidone,Lederle, ,1961
Uses
Different sources of media describe the Uses of 70-07-5 differently. You can refer to the following data:
1. Mephenoxalone is used as a muscle relaxant, also as a mild tranquilizer.
2. Prostaglandin F2á ethyl amide Lumigan (0.03% bimatoprost ophthalmic solution)
3. Muscle relaxant, also used as a mild tranquilizer.
Manufacturing Process
A mixture of 24.1 g (0.10 mol) of 3-o-methoxyphenoxy-2-hydroxy-1-propyl carbamate and 6.0 g (0.10 mol) of urea was heated rapidly to the temperature range of 180°C to 200°C, and maintained there for five hours. The reaction melt was poured into 50% ethyl alcohol, from which the product crystallized as a white solid. The crude yield was 18.3 g (82%); melting point 131.5% to 137°C. Crystallization from water and 95% alcohol gave 9.0 g (40.3 %) of pure 5-o-methoxyphenoxymethyl-2-oxazolidone; melting point 141°C to 143°C. This melting point was not depressed when the material was mixed with an authentic sample. In additional runs acetone was used instead of ethyl alcohol with equivalent results. It was found that when the heating time was reduced to three hours and a reaction temperature of 190°C to 200°C was maintained, equivalent yields (40 to 50%) were obtained, but that the yields were appreciably lowered when the heating time was further reduced to two hours. It was also found that when the temperature was lowered to the range of 170°C to 180°C the yield was significantly lowered.When the material was isolated by extraction with chloroform and distillation,
the yield of pure material was 58.5%.
Brand name
MI. Lenetran (Marion Merrell Dow).
Therapeutic Function
Tranquilizer
Check Digit Verification of cas no
The CAS Registry Mumber 70-07-5 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 0 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 70-07:
(4*7)+(3*0)+(2*0)+(1*7)=35
35 % 10 = 5
So 70-07-5 is a valid CAS Registry Number.
InChI:InChI=1/C11H13NO4/c1-14-9-4-2-3-5-10(9)15-7-8-6-12-11(13)16-8/h2-5,8H,6-7H2,1H3,(H,12,13)
70-07-5Relevant articles and documents
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Pares,Langer
, p. 1862,1863 (1960)
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DMAP-catalyzed synthesis of 2-oxazolidinones from corresponding halohydrins using KOCN/DMF
Chinnam Naidu,Ravi Babu,Gangaiah,Mukkanti,Madhusudhan
experimental part, p. 1226 - 1229 (2010/04/23)
We report facile and simple synthesis of a variety of 2-oxazolidinones from the corresponding halohydrins by reaction with KOCN in DMF catalyzed by DMAP. DMAP and temperature play key roles in enriching the yield of 2-oxazolidinones. A few examples in this Letter are applicable to pharmaceutically important processes.
DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof
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, (2008/06/13)
This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors. This invention further provides a method of treating a subject suffering from urinary incontinence which comprises administering to the subject an amount of an MCH1 antagonist effective to treat the subject's urinary incontinence.
