700-52-7

Basic information

• Product Name: 7-METHYL-5H-[1,3]THIAZOLO[3,2-A]PYRIMIDIN-5-ONE
• Synonyms: 7-METHYL-5H-[1,3]THIAZOLO[3,2-A]PYRIMIDIN-5-ONE;7-Methyl-5H-thiazolo[3,2-a]pyriMidin-5-one
• CAS NO: 700-52-7
• Molecular Formula: C₇H₆N₂OS
• Molecular Weight: 166.2
• Product Categories: Fused Ring Systems
• Mol File: 700-52-7.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-METHYL-5H-[1,3]THIAZOLO[3,2-A]PYRIMIDIN-5-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHYL-5H-[1,3]THIAZOLO[3,2-A]PYRIMIDIN-5-ONE(700-52-7)
• EPA Substance Registry System: 7-METHYL-5H-[1,3]THIAZOLO[3,2-A]PYRIMIDIN-5-ONE(700-52-7)

Safety Data

• Hazardous Substances Data: 700-52-7(Hazardous Substances Data)

Usage

General Description

7-METHYL-5H-[1,3]THIAZOLO[3,2-A]PYRIMIDIN-5-ONE is a heterocyclic compound with the chemical formula C6H5N3OS. It is a thiazolopyrimidinone derivative with a methyl group attached to the nitrogen atom. 7-METHYL-5H-[1,3]THIAZOLO[3,2-A]PYRIMIDIN-5-ONE has a fused ring system consisting of a pyrimidine ring and a thiazole ring, and it is used in the synthesis of various pharmaceutical compounds. Its structure and properties make it suitable for use as a building block in medicinal chemistry, particularly in the development of new drugs for various therapeutic applications.

Upstream product

• 96-50-4 2-thiazolylamine 
• 141-97-9 ethyl acetoacetate 
• 623-46-1 1,2-dichloro-2-ethoxyethane 
• 17356-08-0 thiourea 
• 135351-18-7 (E)-1,1,1-trichloro-4-methoxypent-3-en-2-one 
• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 85811-40-1 7-[(E)-2-(4-Chlorophenyl)vinyl]-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one 
• 1192871-74-1 4-(7-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-6-yl)benzonitrile 
• 1192871-75-2 7-methyl-6-(4-trifluoromethylphenyl)thiazolo[3,2-a]pyrimidin-5-one 

Relevant articles and documents

Practical synthesis of 4H-pyrido[1, 2-a]pyrimidin-4-ones using ethylene glycol as a promoting solvent

A simple and useful protocol leading to different 4H-pyrido[1, 2-a] pyrimidin-4-ones have been established by cyclization of various 2-amino pyridines with β-oxo ester or alkynoate. The use of ethylene glycol was demonstrated to facilitate this condensati

Thiazolo[3,2-a] Pyrimidones as a Novel Anti-TB Agents

A series of novel thiazolo pyrimidine derivatives were designed, synthesized, and assessed for their in vitro anti-mycobacterial activities. All hybrids displayed considerable antitubercular activities against primary Mycobacterium smegmatis mc2 155 screening and successive Mycobacterium tuberculosis H37Rv. In particular, the hybrid entities 13 and 14 (minimum inhibitory concentration: 47 and 39?μg/mL) were found to be equipotent candidates with first-line antitubercular agent rifampicin, which could act as a lead for further optimization.

Synthesis of 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one derivatives

The reaction of 2-aminothiazoles with ethyl acetoacetate in acetic or polyphosphoric acid gave a series of 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one derivatives which were nitrated with a mixture of nitric and sulfuric acid to 6-nitro-5H-[1,3]thiazolo[3,2-a]