70008-26-3

Basic information

• Product Name: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-1,2,6-trimethyl-4-phenyl-, dimethyl ester
• Synonyms: 1,2,6-trimethyl-4-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester;dimethyl 1,4-dihydro-1,2,6-trimethyl-4-phenylpyridine-3,5-dicarboxylate
• CAS NO: 70008-26-3
• Molecular Formula: C18H21NO4
• Molecular Weight: 315.369
• Mol File: 70008-26-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-1,2,6-trimethyl-4-phenyl-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-1,2,6-trimethyl-4-phenyl-, dimethyl ester(70008-26-3)
• EPA Substance Registry System: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-1,2,6-trimethyl-4-phenyl-, dimethyl ester(70008-26-3)

Safety Data

• Hazardous Substances Data: 70008-26-3(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 105-45-3 acetoacetic acid methyl ester 
• 70677-78-0 dimethyl 4-phenyl-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate 
• 74-88-4 methyl iodide 
• 74-89-5 methylamine 
• 23326-27-4 Methyl 2-butynoate 

Downstream Products

• 133349-27-6 3,5-Bis-methoxycarbonyl-1,2,6-trimethyl-4-phenyl-pyridinium 
• 70677-78-0 dimethyl 4-phenyl-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate 
• 77234-00-5 dimethyl 4-phenyl-2,6-dimethyl-3,5-pyridinedicarboxylate 
• 77233-91-1 1-Methyl-2,6-bis-(2-morpholin-4-yl-ethyl)-4-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester; hydrochloride 
• 77233-90-0 2,6-Bis-(2-dimethylamino-ethyl)-1-methyl-4-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester; hydrochloride 
• 75956-20-6 2-(2-Dimethylamino-ethyl)-1,6-dimethyl-4-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester 
• 79209-03-3 dimethyl 1,2,6-trimethyl-t-4-phenyl-1,4,4a,5,6,7-hexahydro-1,6-naphthyridine-3,r-4a-dicarboxylate 
• 79209-04-4 methyl 2,5,8-trimethyl-1-oxo-t-10-phenyl-1,2,3,4,5,7,8,9,9a,10-decahydro-pyrido<4,3-b><1,6>naphthyridine-r-9a-carboxylate 

Relevant articles and documents

Synthesis of pyridinium salts from N-substituted dihydropyridines with BF3OEt2 in the absence of added oxidants

Abstract N-Substituted dihydropyridines were converted into pyridinium salts with BF3OEt2 as aromatization promoter in reactions that could be conducted without the need of the usually added oxidizing agents, such as quinones, nitrat

Gold-catalyzed multicomponent reaction: Facile strategy for the synthesis of N-substituted 1,4-dihydropyridines by using activated alkynes, aldehydes, and methanamine

A convenient and efficient gold-catalyzed multicomponent reaction was developed for the synthesis of a wide range of N-substituted 1,4-dihydropyridines, which are found in a variety of bioactive compounds. This process proceeds smoothly under mild conditions with the use of commercially available substrates and affords the desired products in good to excellent yields. This method provides a highly efficient synthetic route to N-substituted 1,4-dihydropyridines from activated alkynes, aldehydes, and methanamine for which catalytic approaches are scarce. A facile gold-catalyzed strategy for the synthesis of N-substituted 1,4-dihydropyridines is developed through the multicomponent reaction of activated alkynes, aldehydes, and methanamine. The reaction is conducted under convenient conditions and affords the desired compounds in good to excellent yields. Copyright