70010-47-8Relevant articles and documents
Hexafluoroisopropanol as solvent and promotor in the Paal-Knorr synthesis of N-substituted diaryl pyrroles
Schirmacher, Robert H.E.,R?sch, Daniel,Thomas, Franziska
, (2021/02/20)
An additive-free synthesis of challenging N-substituted aryl pyrroles from the often poorly soluble corresponding 1,4-diketones by means of the Paal-Knorr pyrrole synthesis is reported, which makes use of the unique properties of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) as a solvent and reaction promotor. Our procedure offers simple execution and purification as well as easy scale-up and can be applied in the Paal-Knorr synthesis of a large number of structurally diverse pyrroles including the synthetically challenging tetra- and penta-substituted pyrroles in moderate to excellent yields. HFIP can also be used as solvent in the Paal-Knorr synthesis of furans and thiophenes; however, the solvent effect is more pronounced in synthesis of pyrroles.
Environment-responsive multicolor fluorescent dyes based on nitrophenyl or nitrophenylethynyl oligothiophene derivatives: Correlation between fluorescence and π-conjugation length
Hachiya, Sojiro,Asai, Kengo,Konishi, Gen-Ichi
, p. 3317 - 3320 (2013/07/05)
We report the unique environment-responsive fluorescence of nitrophenyl or nitrophenylethynyl oligothiophene derivatives with different numbers of thiophene rings. With an increase in the number of thiophene rings, the maximum fluorescence quantum yield (
HEPATITIS C VIRUS INHIBITORS
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Page/Page column 275, (2011/07/30)
The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS5A protein