70010-48-9Relevant articles and documents
On the trade-off between processability and opto-electronic properties of single wall carbon nanotube derivatives in thin film heterojunctions
Salice, Patrizio,Sartorio, Camillo,Burlini, Alessandro,Improta, Roberto,Pignataro, Bruno,Menna, Enzo
, p. 303 - 312 (2015)
A flow functionalization route has been employed to derivatize single wall carbon nanotubes (SWCNTs) by thienylphenyl groups. The SWCNT derivatives in the most soluble fraction have been characterized by thermogravimetric analysis, DLS analysis, DFT calculations, and UV-vis-NIR, microRaman and IR spectroscopies to study the degree of functionalization, the concentration of SWCNTs in solution, the dimension of the aggregates in solutions, the density of defects, and the presence of the thienylphenyl groups. Thin-film heterojunctions made of SWCNT derivatives and poly(3-hexylthiophene) (P3HT) have been prepared by various methods employing the Langmuir-Schaefer technique, spin-coating and thermal annealing processes. By comparing the batch and the flow functionalizations, a trade-off between solubility, processability and the thin-film opto-electronic properties has been found as a result of the degree of functionalization.
Identification of Piperidine-3-carboxamide Derivatives Inducing Senescence-like Phenotype with Antimelanoma Activities
Oh, Sangmi,Kwon, Do Yoon,Choi, Inhee,Kim, Young Mi,Lee, Ji Young,Ryu, Jiyoung,Jeong, Hangyeol,Kim, Myung Jin,Song, Rita
supporting information, p. 563 - 571 (2021/05/06)
This study evaluated the potential use of senescence-inducing small molecules in the treatment of melanoma. We screened commercially available small-molecule libraries with high-throughput screening and high-content screening image-based technology. Our findings showed an initial hit with the embedded N-arylpiperidine-3-carboxamide scaffold-induced senescence-like phenotypic changes in human melanoma A375 cells without serious cytotoxicity against normal cells. A focused library containing diversely modified analogues were constructed and examined to evaluate the structure-activity relationship of N-arylpiperidine-3-carboxamide derivatives starting from hit 1. This work identified a novel compound with remarkable antiproliferative activity in vitro and demonstrated the key structural moieties within.
COMPOUNDS AND METHODS TO ATTENUATE TUMOR PROGRESSION AND METASTASIS
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Paragraph 0266-0267, (2020/05/28)
This invention relates to certain compounds or pharmaceutically acceptable salts thereof, and for the use of the compounds to treat cancer. In another aspect, the disclosure relates to a pharmaceutical composition comprising a compound of Formula (1), For
Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD?Yap Protein-Protein Interaction
Bum-Erdene, Khuchtumur,Zhou, Donghui,Gonzalez-Gutierrez, Giovanni,Ghozayel, Mona K.,Si, Yubing,Xu, David,Shannon, Harlan E.,Bailey, Barbara J.,Corson, Timothy W.,Pollok, Karen E.,Wells, Clark D.,Meroueh, Samy O.
, p. 378 - 13,389 (2019/03/19)
The Hippo pathway coordinates extracellular signals onto the control of tissue homeostasis and organ size. Hippo signaling primarily regulates the ability of Yap1 to bind and co-activate TEA domain (TEAD) transcription factors. Yap1 tightly binds to TEAD4
