70028-57-8

Basic information

• Product Name: (3-hydroxy-4-methoxy-phenyl)-pyruvic acid
• Synonyms: (3-hydroxy-4-methoxy-phenyl)-pyruvic acid
• CAS NO: 70028-57-8
• Molecular Weight: 210.186
• Mol File: 70028-57-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3-hydroxy-4-methoxy-phenyl)-pyruvic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3-hydroxy-4-methoxy-phenyl)-pyruvic acid(70028-57-8)
• EPA Substance Registry System: (3-hydroxy-4-methoxy-phenyl)-pyruvic acid(70028-57-8)

Safety Data

• Hazardous Substances Data: 70028-57-8(Hazardous Substances Data)

Usage

General Description

(3-hydroxy-4-methoxy-phenyl)-pyruvic acid is a chemical compound with potential biological and pharmaceutical significance. It is a derivative of phenyl-pyruvic acid and contains a hydroxy and a methoxy group on the phenyl ring. (3-hydroxy-4-methoxy-phenyl)-pyruvic acid has been studied for its antioxidant and anti-inflammatory properties, and has shown potential as a therapeutic agent for various diseases. Additionally, it has been investigated for its ability to inhibit the growth of cancer cells and could be a promising candidate for the development of anti-cancer drugs. Further research is needed to fully understand the potential uses and effects of (3-hydroxy-4-methoxy-phenyl)-pyruvic acid in medicinal and pharmacological applications.

Upstream product

• 4368-00-7 5-(3-hydroxy-4-methoxy-benzylidene)-imidazolidine-2,4-dione 
• 621-59-0 isovanillin 

Downstream Products

• 1131-94-8 homoisovanillic acid 
• 113222-75-6 2-methoxy-5-(2,3,4,9-tetrahydro-1H-β-carbolin-1-ylmethyl)-phenol 

Relevant articles and documents

Synthesis, biological evaluation and molecular modeling studies of psammaplin A and its analogs as potent histone deacetylases inhibitors and cytotoxic agents

In this study, a concise synthetic method of psammaplin A was achieved from 3-bromo-4-hydroxybenzaldahyde and hydantoin through a four-step synthesis via Knoevenagel condensation, hydrolysis, oximation and amidation in 37% overall yield. A collection of novel psammaplin A analogs focused on the variations of substituents at the benzene ring and modifications at the oxime moiety were synthesized. Among all the synthesized compounds, 5d and 5e showed better HDAC inhibition than psammaplin A and comparable cytotoxicity against four cancer cell lines (PC-3, MCF-7, A549 and HL-60). Molecular docking and dynamics simulation revealed that (i) hydrogen atom of the oxime group interacts with Asp99 of HDAC1 through a water bridged hydrogen bond and (ii) a hydroxyl group is optimal attached on the para-position of benzene, interacting with Glu203 at the entrance to the active site tunnel.