7003-47-6Relevant articles and documents
Asymmetric Multicomponent Reactions for Efficient Construction of Homopropargyl Amine Carboxylic Esters
Yu, Sifan,Hua, Ruyu,Fu, Xiang,Liu, Gengxin,Zhang, Dan,Jia, Shikun,Qiu, Huang,Hu, Wenhao
, p. 5737 - 5741 (2019)
Developing an efficient and highly enantioselective protocol to access homopropargyl amines is of high interest to the synthetic community and also remains a formidable challenge for organic chemists. Here, we present integrated Rh2(OAc)4- and BINOL-derived chiral phosphoric acid cooperatively catalyzed three-component reactions of alkynyldiazoacetates, imines with various nucleophiles including alcohols, indoles, and N,N-disubstituted anilines, affording the corresponding homopropargyl amines containing two vicinal chiral centers in satisfactory yields with high to excellent diastereo- and enantioselectivities.
Rhodium(II)-vinylcarbenoid insertion into the Si - H bond. A new stereospecific synthesis of allylsilanes
Landais, Yannick,Planchenault, Denis,Weber, Valery
, p. 9549 - 9552 (2007/10/02)
Rh2(OAc)4 catalysed decomposition of vinyldiazocarbonyl compounds in the presence of organosilanes led stereospecifically to the corresponding allylsilanes in good yields. An asymmetric approach has also been considered as well as the extension of the methodology to the synthesis of other allylic systems.
