70030-50-1

Basic information

• Product Name: 2-Butenethioic acid, S-phenyl ester, (2E)-
• CAS NO: 70030-50-1
• Molecular Formula: C10H10OS
• Molecular Weight: 178.255
• Mol File: 70030-50-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-Butenethioic acid, S-phenyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenethioic acid, S-phenyl ester, (2E)-(70030-50-1)
• EPA Substance Registry System: 2-Butenethioic acid, S-phenyl ester, (2E)-(70030-50-1)

Safety Data

• Hazardous Substances Data: 70030-50-1(Hazardous Substances Data)

Upstream product

• 625-35-4 trans-chrotonyl chloride 
• 108-98-5 thiophenol 
• 10487-71-5 crotonyl chloride 
• 1192-40-1 copper(I) thiophenolate 
• 882-33-7 diphenyldisulfane 
• 123-73-9 crotonaldehyde 
• 107-93-7 (E)-but-2-enoic acid 
• 80-59-1 Tiglic acid 
• 5296-64-0 allyl phenyl thioether 
• 201230-82-2 carbon monoxide 

Downstream Products

• 992-67-6 Butenoyl-Coenzyme A 
• 5296-64-0 allyl phenyl thioether 
• 139-66-2 diphenyl sulfide 
• 22103-05-5 1-(phenylthio)-1-propene 
• 3246-27-3 tert-butyl crotonate 
• 90919-09-8 3-chloro-thiobutyric acid S-phenyl ester 

Relevant articles and documents

Discovery and Engineering of Pathways for Production of α-Branched Organic Acids

Cell-based synthesis offers many opportunities for preparing small molecules from simple renewable carbon sources by telescoping multiple reactions into a single fermentation step. One challenge in this area is the development of enzymatic carbon-carbon bond forming cycles that enable a modular disconnection of a target structure into cellular building blocks. In this regard, synthetic pathways based on thiolase enzymes to catalyze the initial carbon-carbon bond forming step between acyl coenzyme A (CoA) substrates offer a versatile route for biological synthesis, but the substrate diversity of such pathways is currently limited. In this report, we describe the identification and biochemical characterization of a thiolase-ketoreductase pair involved in production of branched acids in the roundworm, Ascaris suum, that demonstrates selectivity for forming products with an α-methyl branch using a propionyl-CoA extender unit. Engineering synthetic pathways for production of α-methyl acids in Escherichia coli using these enzymes allows the construction of microbial strains that produce either chiral 2-methyl-3-hydroxy acids (1.1 ± 0.2 g L-1) or branched enoic acids (1.12 ± 0.06 g L-1) in the presence of a dehydratase at 44% and 87% yield of fed propionate, respectively. In vitro characterization along with in vivo analysis indicates that the ketoreductase is the key driver for selectivity, forming predominantly α-branched products even when paired with a thiolase that highly prefers unbranched linear products. Our results expand the utility of thiolase-based pathways and provide biosynthetic access to α-branched compounds as precursors for polymers and other chemicals.

Ionic liquid: An efficient and reusable media for seleno- and thioester synthesis promoted by indium

A series of thio and selenoesters were efficiently obtained employing stable diorganyl chalcogenides, acyl chlorides, and In as reducing agent in BMIM·PF6. Recycling of the ionic liquid was also performed, which was reused three times.

Diels-Alder reactions of α,β-unsaturated thioesters and α,β-unsaturated selenoesters

α,β-Unsaturated thioesters and selenoesters serve as dienophiles in Diels-Alder reactions with a variety of 1,3-dienes. Good levels of regioselectivity are obtained with unsymmetrical dienes when Lewis acid promoters are used. Thioesters and selenoesters