70034-82-1Relevant articles and documents
Incorporation of phenethylisoquinolines into colchicine in isolated seeds of Colchicum autumnale
Nasreen, Amber,Gundlach, Heidrun,Zenk, Meinhart H.
, p. 107 - 115 (1997)
The physiological parameters for application experiments using immature seeds of Colchicum autumnale were optimized, so that incorporation rates in the range of 10% and higher were consistently obtained with intermediate precursors. Application of tritium and 13C-labelled phenethylisoquinolines showed that N-methylation occurs prior to the substitution of ring C and that the free hydroxy group in position 13 of autumnaline is necessary for the phenolic coupling reaction. Autumnaline gives rise to a vast array of metabolites in seeds of this plant.
