70071-22-6

Basic information

• Product Name: 2-(4-chlorophenyl)-3-methylquinoxaline
• Synonyms: 2-(4-chlorophenyl)-3-methylquinoxaline
• CAS NO: 70071-22-6
• Molecular Weight: 254.719
• Mol File: 70071-22-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-(4-chlorophenyl)-3-methylquinoxaline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-3-methylquinoxaline(70071-22-6)
• EPA Substance Registry System: 2-(4-chlorophenyl)-3-methylquinoxaline(70071-22-6)

Safety Data

• Hazardous Substances Data: 70071-22-6(Hazardous Substances Data)

Upstream product

• 6285-05-8 4'-chloropropiophenone 
• 56472-72-1 1-(4-chlorophenyl)-2-(hydroxyimino)propan-1-one 
• 95-54-5 1,2-diamino-benzene 
• 710-20-3 1-chloro-4-(2-nitropropenyl)benzene 
• 79-24-3 Nitroethane 
• 104-88-1 4-chlorobenzaldehyde 
• 877-37-2 2-bromo-1-(4-chlorophenyl)-1-propanone 

Downstream Products

• 1415584-15-4 2-(4-chlorophenyl)-3-vinylquinoxaline 
• 84652-54-0 2-(2-benzo[1,3]dioxol-5-yl-vinyl)-3-(4-chloro-phenyl)-quinoxaline 

Relevant articles and documents

Chemoselective synthesis of quinoxalines and benzimidazoles by silica gel catalysis

Treatment of nitroolefins and o-phenylenediamine with silica gel catalyst produced quinoxalines mainly in THF, but gave benzimidazoles efficiently in water. Such a solvent-dependent chemoselective reaction has prominent features of affording two cyclized products selectively with the same substrate, short reaction time, operational simplicity, as well as available starting materials and nontoxic catalysts. In addition, the scope and limitations were explored and a plausible reaction mechanism is proposed.

Cu(II)-catalyzed synthesis of quinoxalines from o-phenylenediamines and nitroolefins

An easy and efficient copper-catalyzed reaction for the synthesis of quinoxalines from o-phenylenediamines and nitroolefins is developed. This reaction could proceed well without additional base and be applied to various available substrates with a one-step synthetic procedure in moderate to good yields.

A rapid synthesis of quinoxalines starting from ketones

A fast and general synthesis of quinoxalines, performed in two stages or as a one-pot reaction, starting from ketones via their α-hydroxylimino ketone derivatives, and condensation of the latter with 1,2-diaminobenzene under microwave irradiation, is described.