700875-91-8

Basic information

• Product Name: (2S)-2-{(4S)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl}pyrrolidine-1-carboxylic acid benzyl ester
• Synonyms: (2S)-2-{(4S)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl}pyrrolidine-1-carboxylic acid benzyl ester
• CAS NO: 700875-91-8
• Molecular Weight: 316.4
• Mol File: 700875-91-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2S)-2-{(4S)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl}pyrrolidine-1-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-{(4S)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl}pyrrolidine-1-carboxylic acid benzyl ester(700875-91-8)
• EPA Substance Registry System: (2S)-2-{(4S)-4-isopropyl-4,5-dihydro-1,3-oxazol-2-yl}pyrrolidine-1-carboxylic acid benzyl ester(700875-91-8)

Safety Data

• Hazardous Substances Data: 700875-91-8(Hazardous Substances Data)

Upstream product

• 71989-31-6 Fmoc-Pro-OH 
• 103321-52-4 (S)-N-(fluoren-9-ylmethoxycarbonyl)prolyl chloride 
• 72-18-4 L-valine 
• 2026-48-4 (S)-valinol 
• 61350-60-5 (S)-benzyloxycarbonyl-proline acid chloride 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 34079-31-7 Z-Pro-NH₂ 
• 63808-36-6 (2S)-2-cyanopyrrolidine-1-carboxylic acid benzyl ester 
• 936257-82-8 (2S)-{(1S)-1-(hydroxymethyl)-2-methylpropylcarbamoyl}pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester 
• 95924-70-2 *,R^*)>-2-<<<1-(Hydroxymethyl)-2-methylpropyl>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester 

Relevant articles and documents

Distinctive meta-directing group effect for iridium-catalyzed 1,1-diarylalkene enantioselective hydrogenation

An iridium-catalyzed asymmetric hydrogenation of 1,1-diarylkenes is described. Employing a novel, modular phosphoramidite ligand, PhosPrOx, in this transformation affords biologically relevant 1,1-diarylmethine products in good enantiomeric ratios (96.5:3

Synthesis of all-cis-3-(2-diphenylphosphinoethyl)-1,2,4-tris(diphenylphosphinomethyl)cyclopentane (Ditricyp) from dicyclopentadiene

A new tetraphosphine, all-cis-3-(2-diphenylphosphinoethyl)-1,2,4-tris(diphenylphosphinomethyl)cyclopentane (Ditricyp), has been synthesised in seven steps from commercially available dicyclopentadiene. The ozonolysis of dicyclopentadiene occurred first on the double bond of the bicycloheptene moiety. A very high chemoselective ozonolysis was observed at -60 °C leading to the diol after reductive treatment. From this diol, cis,cis,cis-3-(2-hydroxyethyl)-1,2,4-tri(hydroxymethyl)cyclopentane was obtained after a second ozonolysis. Mesylation and substitution with Ph2PLi led to the title tetradiphenylphosphine Ditricyp. The efficiency of this new tetraphosphine ligand for palladium-catalysed coupling reactions has been studied. Satisfactory results in terms of substrate/catalyst ratio have been obtained for Suzuki, Negishi and Sonogashira couplings and also for Heck vinylation reaction. After chromatographic separation, one enantiomer of this ligand associated to palladium was able to induce enantioselective allylic alkylation with modest enantiomeric excess.