701232-68-0Relevant articles and documents
IMMUNOREGULATORY AGENTS
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, (2016/01/27)
Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.
Development of novel benzomorpholine class of diacylglycerol acyltransferase i inhibitors
Zhou, Gang,Zorn, Nicolas,Ting, Pauline,Aslanian, Robert,Lin, Mingxiang,Cook, John,Lachowicz, Jean,Lin, Albert,Smith, Michelle,Hwa, Joyce,Van Heek, Margaret,Walker, Scott
, p. 544 - 549 (2014/06/09)
Diacylglycerol acyltransferase 1 (DGAT1) presents itself as a potential therapeutic target for obesity and diabetes for its important role in triglyceride biosynthesis. Herein we report the rational design of a novel class of DGAT1 inhibitors featuring a
Proton exchange reactions in isotope chemistry (II) synthesis of stable isotope-labeled LCQ908
Jian, Zhigang,Ray, Tapan,Wu, Amy,Jones, Lawrence,Forseth, Ry
, p. 670 - 673 (2015/02/02)
The proton exchange reaction was applied to the preparation of stable isotope-labeled LCQ908. For this synthesis, a suitable intermediate with protons alpha to a carbonyl group was first subjected to the H-D exchange reaction; subsequent coupling of a car