70124-98-0

Basic information

• Product Name: 2-(P-HYDROXYPHENYL)ISOVALERIC ACID
• Synonyms: 2-(P-HYDROXYPHENYL)ISOVALERIC ACID;2-(4-HYDROXYPHENYL)-3-METHYLBUTYRIC ACID;PHPIA;2-(p-Hydroxyphenyl)-3-methylbutanoic acid;2-(4-Hydroxyphenyl)Isovaleric Acid;2-(4-hydroxyphenyl)-3-methylbutanoic acid
• CAS NO: 70124-98-0
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.23
• EINECS: 274-323-2
• Mol File: 70124-98-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 342.8oC at 760 mmHg
• Flash Point: 175.3oC
• Appearance: /
• Density: 1.17g/cm3
• Vapor Pressure: 2.82E-05mmHg at 25°C
• Refractive Index: 1.553
• PKA: 4.47±0.10(Predicted)
• CAS DataBase Reference: 2-(P-HYDROXYPHENYL)ISOVALERIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(P-HYDROXYPHENYL)ISOVALERIC ACID(70124-98-0)
• EPA Substance Registry System: 2-(P-HYDROXYPHENYL)ISOVALERIC ACID(70124-98-0)

Safety Data

• Hazardous Substances Data: 70124-98-0(Hazardous Substances Data)

Usage

General Description

2-(p-hydroxyphenyl)isovaleric acid is a chemical compound with the molecular formula C11H14O3. It is a derivative of valeric acid and contains a hydroxyphenyl group. 2-(P-HYDROXYPHENYL)ISOVALERIC ACID has been identified as a potential biomarker for certain types of cancer and is also being studied for its potential role in the treatment of neurodegenerative diseases. Additionally, 2-(p-hydroxyphenyl)isovaleric acid has been reported to have anti-inflammatory and antioxidant properties, which makes it of interest for potential therapeutic applications. Overall, this compound is a promising target for further research in both biomedical and pharmaceutical fields.

InChI:InChI=1/C11H14O3/c1-7(2)10(11(13)14)8-3-5-9(12)6-4-8/h3-7,10,12H,1-2H3,(H,13,14)

Upstream product

• 51632-18-9 2-(4-methoxyphenyl)-3-methylbutyronitrile 
• 67033-46-9 2-(4-hydroxyphenyl)-3-methylbutyronitrile 
• 2012-81-9 3-Methyl-2-(4'-chlorophenyl)-butyronitrile 
• 12775-96-1 copper 

Downstream Products

• 88149-98-8 methyl-2-(4-hydroxyphenyl)-3-methylbutanoate 
• 110-86-1 pyridine 
• 70124-99-1 ⁽²⁾-2-(4-difluoromethoxyphenyl)-3-methylbutyric acid 
• 72222-35-6 α-Isopropyl-3-bromo-4-hydroxyphenylacetic acid 
• 72222-36-7 α-isopropyl-3-chloro-4-hydroxyphenylacetic acid 
• 72222-37-8 α-isopropyl-3,5-dichloro-4-hydroxyphenylacetic acid 
• 72222-38-9 α-isopropyl-3-nitro-4-hydroxyphenylacetic acid 

Relevant articles and documents

Process for the preparation of 2-(4-hydroxyphenyl)-3-methylbutyric acid

An integrated process for the preparation of 2-(4-hydroxyphenyl)-3-methylbutyric acid from the corresponding 2-(4-chlorophenyl)-3-methylbutyronitrile through hydrolysis of the nitrile by strong base to the corresponding carboxylic acid followed by formation of the corresponding phenol by nucleophilic displacement of the chlorine with a strong base in the presence of copper salts, and if so desired metallic copper, is described.

Method of preparing 4-(α-alkyl-α-cyano-methyl)2,6-di-substituted phenols

4-(α-alkyl-α-cyano-methyl)2,6-di-substituted phenols having the formula STR1 wherein R is methyl, ethyl, n-propyl or isopropyl are prepared by reacting a di-substituted phenol, such as 2,6-di-tertiary-butyl phenol, with a Friedel-Crafts addition agent in the presence of a Friedel-Crafts catalyst such as aluminum chloride to form the corresponding 4-(α-alkyl-α-oxo-methyl)2,6-di-substituted phenol. The 4-(α-alkyl -α-oxo-methyl)2,6-di-substituted phenol thus formed readily can be reduced to form the corresponding 4-(α-alkyl-α-hydroxy-methyl)2,6-di-substituted phenol which thereafter can be reacted with an alkali metal or an alkaline earth metal cyanide to form the desired 4-(α-alkyl-α-cyano-methyl)2,6-di-substituted phenol. This can be converted by hydrolysis into the corresponding α-alkyl-4-hydroxyphenylacetic acid. These acids are well-known insecticidal and acaricidal intermediates.