701266-25-3

Basic information

• Product Name: Silane, (3,5-difluorophenoxy)(1,1-dimethylethyl)diphenyl-
• CAS NO: 701266-25-3
• Molecular Formula: C22H22F2OSi
• Molecular Weight: 368.498
• Mol File: 701266-25-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Silane, (3,5-difluorophenoxy)(1,1-dimethylethyl)diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, (3,5-difluorophenoxy)(1,1-dimethylethyl)diphenyl-(701266-25-3)
• EPA Substance Registry System: Silane, (3,5-difluorophenoxy)(1,1-dimethylethyl)diphenyl-(701266-25-3)

Safety Data

• Hazardous Substances Data: 701266-25-3(Hazardous Substances Data)

Upstream product

• 1178513-71-7 (2-bromo-3,5-difluorophenoxy)(tert-butyl)diphenylsilane 

Downstream Products

• 701269-86-5 (RS)-[2,6-difluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-ethoxy-acetic acid ethyl ester 
• 701269-87-6 (RS)-[4-(6-amino-pyridin-3-yl)-2,6-difluoro-phenyl]-ethoxy-acetic acid 
• 701266-36-6 (RS)-N-(4-carbamimidoyl-benzyl)-2-ethoxy-2-(2,6-difluoro-4-ethoxy-phenyl)-acetamide hydrochloride 
• 701266-31-1 (RS)-N-(4-carbamimidoyl-benzyl)-2-(2,6-difluoro-4-hydroxy-phenyl)-2-ethoxy-acetamide hydrochloride 
• 701266-26-4 (RS)-[4-(tert-butyl-diphenyl-silanyloxy)-2,6-difluoro-phenyl]-hydroxy-acetic acid ethyl ester 

Relevant articles and documents

TBDPS and Br-TBDPS protecting groups as efficient aryl group donors in Pd-catalyzed arylation of phenols and anilines

(Chemical Equation Presented) It is shown that the TBDPS protecting group can serve as an efficient phenyl group donor for o-bromophenols via Pd-catalyzed C-H arylation followed by a routine TBAF deprotection of the resulting silacycles. Employment of the newly designed Br-TBDPS protecting group in the same sequence allows for a facile introduction of a phenyl group at the ortho position of phenols and anilines. Alternatively, switching desilylation to oxidation in the last step allows the conversion of forming silacycles into valuable o-biphenols.