70129-83-8

Basic information

• Product Name: 1-Iodo-4-methylnaphthalene
• Synonyms: 1-Iodo-4-methylnaphthalene
• CAS NO: 70129-83-8
• Molecular Formula: C₁₁H₉I
• Molecular Weight: 268.09363
• Mol File: 70129-83-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Iodo-4-methylnaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Iodo-4-methylnaphthalene(70129-83-8)
• EPA Substance Registry System: 1-Iodo-4-methylnaphthalene(70129-83-8)

Safety Data

• Hazardous Substances Data: 70129-83-8(Hazardous Substances Data)

Usage

Chemical composition

A naphthalene ring with a methyl group and an iodine atom attached to it.

Usage

Building block in organic synthesis, specifically in the production of pharmaceuticals and agrochemicals.

Application

Preparation of various heterocycles and organic compounds with potential biological activities.

Value

Unique structure and reactivity for creating complex molecular structures in organic chemistry.

Hazard

Considered hazardous and may cause irritation to the skin, eyes, and respiratory system upon exposure.

Upstream product

• 4523-45-9 1-amino-4-methylnaphthalene 
• 402475-94-9 1-(iodoethynyl)-2-(1-methylethenyl)benzene 
• 90-12-0 1-Methylnaphthalene 
• 6627-78-7 1-bromo-4-methylnaphthalene 

Downstream Products

• 863305-32-2 diphenic acid 
• 855292-50-1 2-(4-methyl-[1]naphthyl)-benzoic acid 

Relevant articles and documents

Rhenium-Catalyzed Cyclization via 1,2-Iodine and 1,5-Hydrogen Migration for the Synthesis of 2-Iodo-1 H-indenes

A rhenium complex catalyzed the formation of 2-iodo-1H-indene derivatives through iodine and hydrogen migration of 3-iodopropargyl ethers. The reaction proceeded via generation of 1-iodoalkenylrhenium carbene species by sequential 1,2-iodine and 1,5-hydro

An Unprecedented, Lewis Acid-Mediated, Metal-Free Iodoannulation Strategy to Aromatic Iodides

A direct transformation of ortho-alkynylated aromatic vinyl ethers to 1-iodonaphthalenes and other iodo-heterocycles under mild Lewis acidic conditions in the presence of iodide as an external nucleophile is reported. The first example of an iodoannulation strategy using a nucleophilic source of iodine, coupled with good to excellent yields, exclusive alpha regioselectivity and a broad substrate scope makes this work an attractive avenue towards the construction of aromatic iodides.

Efficient and direct iodination of alkyl benzenes using polymer/HIO4 and I2 under mild condition

An efficient and rapid method has been found for the iodination of aromatic compounds using iodine and polymer-supported periodic acid (PSPIA) as an oxidant under mild aprotic conditions. The reagent after the completion of the reaction was easily removed by filtration and was regenerated for further use. This method has some advantages such as: mild reaction conditions, straight forward procedure, inexpensive method, high yields and one-pot conversion.