70150-84-4

Basic information

• Product Name: 3-Furancarboxylic acid, hydrazide
• Synonyms: furan-3-carbohydrazide;3-furoic hydrazide;3-furancarboxylic acid hydrazide;furan-3-carboxylic acid hydrazide;3-furoylcarbohydrazide;Furan-3-carbonsaeure-hydrazid
• CAS NO: 70150-84-4
• Molecular Formula: C5H6N2O2
• Molecular Weight: 126.11300
• Mol File: 70150-84-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 3-Furancarboxylic acid, hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Furancarboxylic acid, hydrazide(70150-84-4)
• EPA Substance Registry System: 3-Furancarboxylic acid, hydrazide(70150-84-4)

Safety Data

• Hazardous Substances Data: 70150-84-4(Hazardous Substances Data)

Upstream product

• 488-93-7 3-Furoic acid 
• 13129-23-2 methyl furan-3-carboxylate 
• 83124-80-5 3-trichloroacetyl-4,5-dihydrofuran 
• 743420-66-8 2,2,2-trichloro-1-(furan-3-yl)ethan-1-one 
• 614-98-2 ethyl 3-furancarboxylate 

Downstream Products

• 113398-18-8 (5-Furan-3-yl-[1,3,4]oxadiazol-2-ylmethyl)-carbamic acid benzyl ester 
• 1246513-00-7 2-(furan-3-yl)-5-phenyl-1,3,4-oxadiazole 
• 1622868-11-4 C₁₆H₁₂N₂O₄ 
• 1412407-31-8 C₁₉H₂₂N₄O₂S 

Relevant articles and documents

Ruthenium-Catalyzed Three-Component Alkylation: A Tandem Approach to the Synthesis of Nonsymmetric N,N-Dialkyl Acyl Hydrazides with Alcohols

The borrowing hydrogen strategy has been applied in the synthesis of nonsymmetric N,N-dialkylated acyl hydrazides via a tandem three-component reaction catalyzed by a phosphine free diaminocyclopentadienone ruthenium tricarbonyl complex. This strategy represents the first direct one-pot approach to nonsymmetric functionalized acyl hydrazides. Different aromatic acyl hydrazides underwent dialkylation with a variety of primary or secondary alcohols and methanol or ethanol as alkylating agents in mild reaction conditions and good yields. Deuterium labelling experiments suggested that the primary or secondary alcohol was the hydrogen source in this tandem process. DFT calculations show that the combination of the tandem mixed product cannot be perfectly explained neither structurally nor electronically, but might be dependent of the physical state of the aldehyde or ketone intermediate (gaz vs. liquid) at the reaction temperature. (Figure presented.).

NOVEL AZOLE DERIVATIVES AS APELIN RECEPTOR AGONIST

The present invention relates to a novel azole derivative as an apelin receptor agonist and a method for treating cardiovascular disease, diabetic disease, renal disease, hypertension, and arteriosclerosis, etc., using the same. The present invention provides a compound represented by formula (I) or a pharmacologically acceptable salt thereof wherein X1 represents -N= or -CH=, X2 represents -CH= or -N=, R1 and R2 each represent a C1 to C6 alkoxy group or the like, R3 represents a heteroaryl group (the heteroaryl group is optionally substituted by a methyl group or the like) or the like, and R4 represents a C1 to C6 alkylthio group or a C2 to C6 alkenyl group (the C1 to C6 alkylthio group and the C2 to C6 alkenyl group are each optionally substituted by one carboxy group or the like) or the like.

NOVEL N-OXIDES OF FURANYL-OXADIAZOLYL-DIAZABICYCLONONANE DERIVATIVES AND THEIR MEDICAL USE

This invention relates to novel N-oxides of certain furanyl-oxadiazolyl-diazabicyclononane derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.