70160-48-4Relevant articles and documents
An organometallic route to 2'-hydroxy-6'-methoxy-acetophenone
Mincheva,Velkov,Boireau,Barry,Fugier
, p. 149 - 155 (1995)
2'-Hydroxy-6'-methoxyacetophenone was obtained in 66% yield from 3-methoxyphenol. In the key step, 3-methoxyphenol protected by means of ethylvinyl ether was selectively metallated at the 2-position with butyllithium. Addition of ZnCl2 to the aryllithium gave the corresponding organozinc compound, which readily reacted on acetyl chloride under palladium catalysis.
5-Oxy-substituted-3-aminochroman compounds, processes for their preparation, pharmaceutical compositions containing them and methods of treatment therewith
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, (2008/06/13)
A compound of the formula wherein R1 is a saturated or unsaturated alkyl group having 1-5 carbon atoms or a phenylalkyl group, whereby the phenyl ring may be substituted or unsubstituted and the alkyl having 1-4 carbon atoms, R2 is hydrogen or an alkyl group having 1-5 carbon atoms, or R1 and R2 together form a 5- or 6-membered ring containing 1 or 2 heteroatoms selected from N, O and S, and enantiomers and physiologically acceptable salts thereof, processes for preparation of said compounds, pharmaceutical preparations containing said compounds, use of and method of treatment of disorders in CNS by using said compounds and intermediates.