701976-55-8 Usage
General Description
"SH-6" is a small molecule inhibitor that has been found to have potential therapeutic applications in various fields, including cancer and inflammation. It has been shown to inhibit the activity of a key enzyme called sphingosine kinase, which is involved in the regulation of cell growth, survival, and migration. By blocking the activity of this enzyme, "SH-6" has the potential to inhibit cancer cell growth and metastasis, as well as reduce inflammation in diseases such as arthritis and inflammatory bowel disease. Additionally, "SH-6" has been studied for its potential neuroprotective effects, as it may have the ability to protect against oxidative stress and apoptosis in the central nervous system. Overall, "SH-6" shows promise as a versatile and potentially valuable therapeutic agent in multiple disease settings.
Check Digit Verification of cas no
The CAS Registry Mumber 701976-55-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,0,1,9,7 and 6 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 701976-55:
(8*7)+(7*0)+(6*1)+(5*9)+(4*7)+(3*6)+(2*5)+(1*5)=168
168 % 10 = 8
So 701976-55-8 is a valid CAS Registry Number.
701976-55-8Relevant articles and documents
Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt
Kozikowski, Alan P.,Sun, Haiying,Brognard, John,Dennis, Phillip A.
, p. 1144 - 1145 (2007/10/03)
The synthesis from l-quebrachitol of a series of 3-deoxygenated ether lipid-type phosphatidylinositol (PI) analogues is reported, that selectively block activation of Akt and downstream substrates without affecting activation of the upstream kinase, PDK-1
