702-24-9

Basic information

• Product Name: N-(4-Methoxybenzyl)-N-methylamine
• Synonyms: AKOS BC-0897;(4-METHOXY-BENZYL)-METHYL-AMINE;4-METHOXY-N-METHYLBENZYLAMINE;N-(4-METHOXYBENZYL)-N-METHYLAMINE;N-Methyl-4-methoxybenzylamine;4-METHOXY-N-METHYLBENZYLAMINE 95%;(4-methoxyphenyl)-N-methylmethanamine;1-(4-methoxyphenyl)-N-methylmethanamine
• CAS NO: 702-24-9
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.21
• EINECS: 200-002-4
• Product Categories: Amines and Anilines
• Mol File: 702-24-9.mol
• Article Data: 51

Chemical Properties

• Melting Point: 238 °C
• Boiling Point: 88 °C
• Flash Point: 109℃
• Appearance: colorless liquid.
• Density: 1.008 g/mL at 25 °C
• Vapor Pressure: 0.104mmHg at 25°C
• Refractive Index: n20/D1.529
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 10.14±0.10(Predicted)
• CAS DataBase Reference: N-(4-Methoxybenzyl)-N-methylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Methoxybenzyl)-N-methylamine(702-24-9)
• EPA Substance Registry System: N-(4-Methoxybenzyl)-N-methylamine(702-24-9)

Safety Data

• Hazard Codes: C,Xn
• Statements: 36/37/38-34-22
• Safety Statements: 26-36/37/39
• RIDADR: UN 2735 8/PG III
• WGK Germany: 1
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 702-24-9(Hazardous Substances Data)

Usage

Uses

N-(4-Methoxybenzyl)-N-methylamine is used in the synthetic preparation of many types of compounds, including the synthesis of trifluoromethyl-sulfonimidamides from sulfinamides as well as the preparation of piperazinylquinazoline amine compounds as toll-like receptor 9 signaling antagonists for treatment of immune disorders.

InChI:InChI=1/C9H13NO/c1-10-7-8-3-5-9(11-2)6-4-8/h3-6,10H,7H2,1-2H3/p+1

Upstream product

• 32872-35-8 N-methyl-p-methoxythiobenzamide 
• 5129-86-2 N-(4-methoxybenzyl)-N-methylformamide 
• 2746-25-0 p-Methoxybenzyl bromide 
• 74-89-5 methylamine 
• 123-11-5 4-methoxy-benzaldehyde 
• 824-94-2 p-methoxybenzyl chloride 
• 3400-22-4 4-methoxy-N-methylbenzamide 
• 13114-23-3 4-methoxybenzyl-N-methylimine 
• 15175-54-9 N,N-dimethyl-4-methoxylbenzylamine 
• 17061-63-1 N-(4-methoxybenzyl)formamide 
• 13114-23-3 N-p-methoxybenzylidenemethylamine 
• 593-51-1 methylamine hydrochloride 
• 6214-20-6 methyl 4-nitrobenzenesulfonate 
• 2393-23-9 4-methoxy-benzylamine 

Downstream Products

• 128942-64-3 2-[(4-methoxy-benzyl)-methyl-amino]-1-phenyl-ethanol 
• 78507-19-4 4-[(methylamino)methyl]phenol 
• 372117-85-6 (3-chloro-4-methoxy-benzyl)-methyl-amine 
• 645378-58-1 (3-bromo-4-methoxy-benzyl)-methyl-amine 
• 122908-74-1 N-(4-methoxybenzyl)-N-methylbenzamide 
• 91247-70-0 (4-methoxy-benzyl)-methyl-carbamic acid methyl ester 
• 110932-36-0 (4-methoxy-benzyl)-methyl-[1]naphthylmethyl-amine 
• 55245-86-8 N‐[(4‐methoxyphenyl)methyl]‐N‐methylcarbamoyl chloride 

Relevant articles and documents

Design, Synthesis, and Biological Evaluation of Novel 3-Aminomethylindole Derivatives as Potential Multifunctional Anti-Inflammatory and Neurotrophic Agents

The development of multifunctional molecules that are able to simultaneously interact with several pathological components has been considered as a solution to treat the complex pathologies of neurodegenerative diseases. Herein, a series of aminomethylindole derivatives were synthesized, and evaluation of their application for antineuroinflammation and promoting neurite outgrowth was disclosed. Our initial screening showed that most of the compounds potently inhibited lipopolysaccharide (LPS)-stimulated production of NO in microglial cells and potentiated the action of NGF to promote neurite outgrowth of PC12 cells. Interestingly, with outstanding NO/TNF-α production inhibition and neurite outgrowth-promoting activities, compounds 8c and 8g were capable of rescuing cells after injury by H2O2. Their antineuroinflammatory effects were associated with the downregulation of the LPS-induced expression of the inflammatory mediators inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Western blotting and immunofluorescence assay results indicated that the mechanism of their antineuroinflammatory actions involved suppression of the MAPK/NF-κB signal pathways. Further studies revealed that another important reason for the high comprehensive antineuroinflammatory activity was the anti-COX-2 capabilities of the compounds. All these results suggest that the potential biochemical multifunctional profiles of the aminomethylindole derivatives provide a new sight for the treatment of neurodegenerative diseases.

HALOALLYLAMINE PYRAZOLE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF

The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as i

Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization

Nowadays, the increasing of multidrug-resistant pathogenic bacteria represents a serious threat to public health, and the lack of new antibiotics is becoming a global emergency. Therefore, research in antibacterial fields is urgently needed to expand the currently available arsenal of drugs. We have recently reported an alkyl-guanidine derivative (2), characterized by a symmetrical dimeric structure, as a good candidate for further developments, with a high antibacterial activity against both Gram-positive and Gram-negative strains. In this study, starting from its chemical scaffold, we synthesized a small library of analogues. Moreover, biological and in vitro pharmacokinetic characterizations were conducted on some selected derivatives, revealing notable properties: broad-spectrum profile, activity against resistant clinical isolates, and appreciable aqueous solubility. Interestingly, 2 seems neither to select for resistant strains nor to macroscopically alter the membranes, but further studies are required to determine the mode of action.