702-82-9Relevant articles and documents
3-(dimethylaminomethyl) piperidine-4-alcohol derivative as well as preparation method and pharmaceutical application thereof
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Paragraph 0206-0210, (2021/05/08)
The present invention provides compounds of formula (FWBF) or pharmaceutically acceptable salts thereof, in which the substituents are as defined in the specification, as well as a preparation method and pharmaceutical use thereof.
Ozone-Mediated Amine Oxidation and Beyond: A Solvent-Free, Flow-Chemistry Approach
Skrotzki, Eric A.,Vandavasi, Jaya Kishore,Newman, Stephen G.
, p. 14169 - 14176 (2021/06/30)
Ozone is a powerful oxidant, most commonly used for oxidation of alkenes to carbonyls. The synthetic utility of other ozone-mediated reactions is hindered by its high reactivity and propensity to overoxidize organic molecules, including most solvents. This challenge can largely be mitigated by adsorbing both substrate and ozone onto silica gel, providing a solvent-free oxidation method. In this manuscript, a flow-based packed bed reactor approach is described that provides exceptional control of reaction temperature and time to achieve improved control and chemoselectivity over this challenging transformation. A powerful method to oxidize primary amines into nitroalkanes is achieved. Examples of pyridine, C-H bond, and arene oxidations are also demonstrated, confirming the system is generalizable to diverse ozone-mediated processes.
3 - Amino -1 - adamantanol and preparation method and application thereof
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Paragraph 0028; 0030-0045, (2021/10/02)
The invention relates to the technical field of chemical synthesis preparation, in particular to 3 - amino -1 - adamantanol and a preparation method and application thereof. The method comprises the following steps. After a period of time, crushed ice is added, and then crushed ice is added until the reaction solution becomes clear ink green, pH values are adjusted to obtain the product, and the product is refluxed and filtered through the organic solution A and the organic solution B, respectively. After drying, 3 - amino -1 - adamantane is obtained. The 3 - amino -1 - adamantanol with high yield can be obtained through cheap and easily available raw materials and simple operation, and the method is low in cost, fast in reaction and more suitable for industrial production.