70200-18-9

Basic information

• Product Name: Benzenepropanoic acid, b-hydroxy-2-methoxy-, ethyl ester
• Synonyms: 3-Hydroxy-3-(2-methoxy-phenyl)-propionic acid ethyl ester;ethyl 3-hydroxy-3-(2-methoxyphenyl)propanoate;Ethyl-3-hydroxy-3-(o-methoxyphenyl)-propionat;ethyl 3-hydroxy-3-(2-methoxyphenyl)propionate;(-)-ethyl 3-(2-methoxyphenyl)-3-hydroxypropionate
• CAS NO: 70200-18-9
• Molecular Formula: C12H16O4
• Molecular Weight: 224.257
• Mol File: 70200-18-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 127 °C (5 mmHg)
• Density: 1.135±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzenepropanoic acid, b-hydroxy-2-methoxy-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, b-hydroxy-2-methoxy-, ethyl ester(70200-18-9)
• EPA Substance Registry System: Benzenepropanoic acid, b-hydroxy-2-methoxy-, ethyl ester(70200-18-9)

Safety Data

• Hazardous Substances Data: 70200-18-9(Hazardous Substances Data)

Upstream product

• 41607-95-8 3-(2-methoxy-phenyl)-3-oxo-propionic acid ethyl ester 
• 141-78-6 ethyl acetate 
• 135-02-4 ortho-anisaldehyde 
• 4071-88-9 trimethylsilanyl-acetic acid ethyl ester 
• 105-36-2 ethyl bromoacetate 
• 623-48-3 ethyl iodoacetae 

Downstream Products

• 41607-95-8 3-(2-methoxy-phenyl)-3-oxo-propionic acid ethyl ester 
• 138307-08-1 (+)-ethyl 3-(2-methoxyphenyl)-3-hexanoyloxypropionate 

Relevant articles and documents

Rate Enhancement in CAN-Promoted Pd(PPh3)2Cl2-Catalyzed Oxidative Cyclization: Synthesis of 2-Ketofuran-4-carboxylate Esters

Stoichiometric ceric ammonium nitrate (CAN) and a catalytic amount of Pd(PPh3)2Cl2 (5 mol %) can rapidly produce multisubstituted 2-ketofuran-4-carboxylate esters from 2-propargylic 1,3-ketoesters via oxidative O-cyclization reaction. Pd(PPh3)2Cl2 was found to be the crucial catalyst as its inclusion greatly enhanced the rate of the reaction and cleanly afforded the products within minutes. Over 30 substrates were successfully converted to the desired compounds in mostly moderate to good yields.

Synthesis, molecular docking and kinetic properties of β-hydroxy- β-phenylpropionyl-hydroxamic acids as Helicobacter pylori urease inhibitors

Inhibition of urease results in Helicobacter pylori growth arrest in the stomach, promoting urease as promising targets for gastrointestinal ulcer therapy. Twenty hybrid derivatives of flavonoid scaffold and hydroxamic acid, β-hydroxy-β-phenylpropionylhydroxamic acids, were therefore synthesized and evaluated against H. pylori urease. Biological evaluation of these compounds showed improved urease inhibition exhibiting micromolar to mid-nanomolar IC50 values. Most importantly, 3-(3-chlorophenyl)-3- hydroxypropionyl-hydroxamic acid (6g) exhibited high potency with IC 50 of 0.083 ± 0.004 μM and Ki of 0.014 ± 0.003 μM, indicating that 6g is an excellent candidate to develop novel antiulcer agent. A mixture of competitive and uncompetitive mechanism was putatively proposed to understand the inconsistency between the crystallographic and kinetic studies for the first time, which is supported by our molecular docking studies.

P(i-PrNCH2CH2)3N: Efficient catalyst for synthesizing β-hydroxyesters and α,β-unsaturated esters using α-trimethylsilylethylacetate (TMSEA)

(Chemical Equation Presented) We present an efficient synthesis of β-hydroxyesters and R,β-unsaturated esters via activation of the silicon-carbon bond of α-trimethylsilylethylacetate using catalytic amounts of the commercially available P(i-PrNCH2CH2) 3N 1a. Selectivity for either of these two products can be achieved simply by altering the catalyst loading and reaction temperature to afford addition or stereoselective condensation. This method is mild and tolerates a wide array of functional groups.