70208-22-9

Basic information

• Product Name: (E)-3-((1S,9bS)-2-Oxo-9b-p-tolyl-1,4,5,9b-tetrahydro-2H-azeto[2,1-a]isoquinolin-1-ylamino)-but-2-enoic acid ethyl ester
• CAS NO: 70208-22-9
• Molecular Weight: 390.482
• Mol File: 70208-22-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-3-((1S,9bS)-2-Oxo-9b-p-tolyl-1,4,5,9b-tetrahydro-2H-azeto[2,1-a]isoquinolin-1-ylamino)-but-2-enoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-((1S,9bS)-2-Oxo-9b-p-tolyl-1,4,5,9b-tetrahydro-2H-azeto[2,1-a]isoquinolin-1-ylamino)-but-2-enoic acid ethyl ester(70208-22-9)
• EPA Substance Registry System: (E)-3-((1S,9bS)-2-Oxo-9b-p-tolyl-1,4,5,9b-tetrahydro-2H-azeto[2,1-a]isoquinolin-1-ylamino)-but-2-enoic acid ethyl ester(70208-22-9)

Safety Data

• Hazardous Substances Data: 70208-22-9(Hazardous Substances Data)

Upstream product

• 61305-03-1 1-(4'-methylphenyl)-3,4-dihydroisoquinoline 
• 32085-79-3 potassium α-methyl-β-ethoxycarbonylethenylaminoacetate 

Downstream Products

• 62333-79-3 (1S,9bS)-1-Amino-9b-p-tolyl-1,4,5,9b-tetrahydro-azeto[2,1-a]isoquinolin-2-one 

Relevant articles and documents

Some Novel Monocyclic cis-β-Lactams from Glycine

Enamine derivatives (Ia, b) obtained by the condensation of glycine and β-dicarbonyl compounds have been utilised for the stereoselective synthesis of cis-β-lactams.Addition of POCl3 to a mixture of the potassium salts (I), imines (IIa-c and III) and triethylamine gives 3-enamino-2-azetidinones (IV, VI, VII, X and XXI) in 30-40 percent yield.Imines (IId and IIe) prepared from ethyl glycinate hydrochloride and aromatic aldehydes, when subjected to this reaction yield 3-enamino-β-lactams (XIII and XVII) carrying an ester function.The protecting β-dicarbonyl function canbe easily removed with ethanol/HCl to generate the α-amino-β-lactams (V, VIII, XI, XIV, XVIII and XXII) which have been used as the progenitors for the preparation of 3-amido-2-azetidinones.The α-amido-β-lactams (XV and XIX) having an ester function on treatment with 0.1 N NaOH in acetone get converted into the novel α-amido-β-lactams (XVI and XX) carrying a free carboxy function essential for antibacterial activity.