70209-81-3

Basic information

• Product Name: Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-
• Synonyms: Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-;avermectin H2B1b;Component B1b;22,23-Dihydro-34-nor-5-O-demethylavermectin A1a;22,23-Dihydro-5-O-demethyl-25-de(1-methylpropyl)-25-isopropylavermectin A1a;22,23-Dihydroavermectin B1b;5-O-Demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)avermectin A1a;Ivermectin B1b
• CAS NO: 70209-81-3
• Molecular Formula: C47H72O14
• Molecular Weight: 861.06618
• EINECS: 274-384-5
• Mol File: 70209-81-3.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 934.1°C at 760 mmHg
• Flash Point: 267.2°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.566
• PKA: 12.42±0.70(Predicted)
• CAS DataBase Reference: Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-(70209-81-3)
• EPA Substance Registry System: Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-(70209-81-3)

Safety Data

• RIDADR: 2588
• HazardClass: 6.1(a)
• PackingGroup: II
• Hazardous Substances Data: 70209-81-3(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 70209-81-3 differently. You can refer to the following data:
1. Ivermectin B1b (dihydroavermectin B1b) is the minor component (<20%) of the commercial anthelmintic, ivermectin. Members of the avermectin/milbemycin anthelmintic class exert their anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells. The avermectin/milbemycins are also potent insecticides. In vitro, the B1b (25-iso-propyl) analogue is slightly more potent than the 25-sec-butyl (B1a) analogue as an inhibitor of nematode larval development and paralysis, and also a more sensitive probe for ivermectin resistance.
2. Ivermectin B1b is a minor component of Ivermectin (I940800), a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.

Definition

ChEBI: A macrocyclic lactone that is avermectin B1b in which the double bond present in the spirocyclic ring system has been reduced to a single bond. It is the minor component of ivermectin.

InChI:InChI=1/C47H72O14/c1-24(2)41-27(5)16-17-46(61-41)22-33-19-32(60-46)15-14-26(4)42(25(3)12-11-13-31-23-54-44-39(48)28(6)18-34(45(50)57-33)47(31,44)51)58-38-21-36(53-10)43(30(8)56-38)59-37-20-35(52-9)40(49)29(7)55-37/h11-14,18,24-25,27,29-30,32-44,48-49,51H,15-17,19-23H2,1-10H3/b12-11+,26-14+,31-13+/t25-,27-,29-,30-,32+,33-,34-,35+,36-,37-,38-,39+,40-,41+,42-,43-,44+,46+,47+/m0/s1