7022-17-5

Basic information

• Product Name: Methanesulfonamide, N-(2-methylphenyl)-
• Synonyms: Methansulfonsaeure-o-toluidid;N-o-tolylmethanesulfonamide;N-(o-tolyl)methanesulfonamide;methanesulfonic acid o-toluidide;N-(2-tolyl)-methanesulfonamide;N-(2-methylphenyl)methanesulfonamide
• CAS NO: 7022-17-5
• Molecular Formula: C8H11NO2S
• Molecular Weight: 185.247
• Mol File: 7022-17-5.mol
• Article Data: 13

Chemical Properties

• Melting Point: 44 °C
• Boiling Point: 292.2±33.0 °C(Predicted)
• Density: 1.267±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Methanesulfonamide, N-(2-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonamide, N-(2-methylphenyl)-(7022-17-5)
• EPA Substance Registry System: Methanesulfonamide, N-(2-methylphenyl)-(7022-17-5)

Safety Data

• Hazardous Substances Data: 7022-17-5(Hazardous Substances Data)

Upstream product

• 3144-09-0 methanesulfonamide 
• 195062-59-0 2-methylphenylboronic acid pinacol ester 
• 124-63-0 methanesulfonyl chloride 
• 95-53-4 o-toluidine 
• 615-37-2 ortho-methylphenyl iodide 
• 95-46-5 2-methylphenyl bromide 
• 95-49-8 2-methylchlorobenzene 

Downstream Products

• 91642-32-9 Methansulfonsaeure-<2-methyl-N.4-diacetyl-anilid> 
• 93884-06-1 3'-Methyl-4'-((methylsulfonyl)amino)acetophenone 
• 88131-55-9 N-(2,2-Diethoxy-ethyl)-N-o-tolyl-methanesulfonamide 
• 88131-59-3 N-(3,3-Diethoxy-propyl)-N-o-tolyl-methanesulfonamide 
• 330468-71-8 methanesulfonic acid-(4-bromo-2-methyl-anilide) 
• 109495-73-0 N-(4-chloro-2-methylphenyl)methanesulfonamide 
• 115003-20-8 methanesulfonic acid-(2,3,4,5-tetrachloro-6-methyl-anilide) 

Relevant articles and documents

Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds

Targeting the protein-protein interaction (PPI) between nuclear factor erythroid 2-related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1) is a potential therapeutic strategy to control diseases involving oxidative stress. Here, six classes of known small-molecule Keap1-Nrf2 PPI inhibitors were dissected into 77 fragments in a fragment-based deconstruction reconstruction (FBDR) study and tested in four orthogonal assays. This gave 17 fragment hits of which six were shown by X-ray crystallography to bind in the Keap1 Kelch binding pocket. Two hits were merged into compound 8 with a 220-380-fold stronger affinity (Ki = 16 μM) relative to the parent fragments. Systematic optimization resulted in several novel analogues with Ki values of 0.04-0.5 μM, binding modes determined by X-ray crystallography, and enhanced microsomal stability. This demonstrates how FBDR can be used to find new fragment hits, elucidate important ligand-protein interactions, and identify new potent inhibitors of the Keap1-Nrf2 PPI.

1,3,4-OXADIAZOLE SULFONAMIDE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to novel compounds represented by the formula I having histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. (I) The novel compounds, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases.

Palladium-Catalyzed cascade sp2 c?H bond functionalizations allowing one-Pot access to 4?Aryl-1,2,3,4-tetrahydroquinolines from n?Allyl?N?arylsulfonamides

We have developed a palladium-catalyzed cascade reaction allowing an efficient synthesis of 4-aryl-1,2,3,4-tetrahydroquinolines from N-allyl-N-arylsulfonamides and benzenesulfonyl chlorides. In this transformation, two C(sp2)?C(sp3) bonds were formed via activation of C(sp2)?H bonds. The reaction proceeds using the easily accessible catalyst PdCl2, with Li2CO3 as inexpensive base and CuBr as additive, and tolerates a wide variety of substituents on both reaction partners.