70230-69-2Relevant articles and documents
3-Methylinosine
Itaya, Taisuke,Matsumoto, Hiroo
, p. 2213 - 2219 (2007/10/02)
3-Methylinosine (2a) has been prepared in 28 percent yield by heating 5-(methylamino)-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)imidazole-4-carboxamide (5c) with a mixture of ethyl orhtoformate and acetic anhydride, followed by ammonololysis.Compound 2a gave the stable 1,2-dihydro derivative 6 in 77 percent yield on catalytic hydrogenation over Pd-C.The pyrimidine moiety of 2a has been shown to undergo ring cleavage under alkaline conditions at a rate three times faster than that of 3,9-dimethylhypoxanthine (3a).The glycosidic bond of 2a is unusually susceptible to acidic hydrolysis and the rate was shown to be faster than that of inosine by a factor of 104.