70254-52-3

Basic information

• Product Name: Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate
• Synonyms: 3-PYRIDINECARBOXYLIC ACID, 2,4-DIHYDROXY-6-METHYL-,ETHYL ESTER;2,4-DIHYDROXY-6-METHYL-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER;BUTTPARK 153\57-17;ETHYL ESTER 2,4-DIHYDROXY-6-METHYL-3-PYRIDINE CARBOXYLIC ACID;ETHYL 2,4-DIHYDROXY-6-METHYL-3-PYRIDINECARBONATE;ETHYL 2,4-DIHYDROXY-6-METHYL-3-PYRIDINECARBOXYLATE;ETHYL 2,4-DIHYDROXY-6-METHYLNICOTINATE;ETHYL 2,4-DIHYDROXY-6-METHYLPYRIDINE-3-CARBOXYLATE
• CAS NO: 70254-52-3
• Molecular Formula: C₉H₁₁NO₄
• Molecular Weight: 197.19
• EINECS: 2017-001-1
• Product Categories: blocks;Carboxes;Pyridines;Esters;Pyridine;Heterocycle-Pyridine series
• Mol File: 70254-52-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 205 °C
• Boiling Point: 363.155ºC at 760 mmHg
• Flash Point: 173.43ºC
• Appearance: /
• Density: 1.555g/cm3
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 8.08±0.28(Predicted)
• CAS DataBase Reference: Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate(70254-52-3)
• EPA Substance Registry System: Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate(70254-52-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37
• HazardClass: IRRITANT
• Hazardous Substances Data: 70254-52-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H7NO4/c1-3-2-4(9)5(7(11)12)6(10)8-3/h2H,1H3,(H,11,12)(H2,8,9,10)

Upstream product

• 626-34-6 ethyl aminocrotonate 
• 105-53-3 diethyl malonate 

Downstream Products

• 846576-77-0 2,4-dihydroxy-6-methyl-5-(4-nitro-phenylsulfanyl)-nicotinic acid ethyl ester 
• 3749-51-7 2,4-dihydroxy-6-methylpyridine 
• 404875-97-4 2,4-dichloro-6-methyl-nicotinoyl chloride 
• 86129-63-7 ethyl 2,4-dichloro-6-methylpyridine-3-carboxylate 
• 344443-57-8 ethyl 2,4-dihydroxy-5-nitro-6-methylpyridine-3-carboxylate 
• 3749-51-7 4-hydroxy-6-methyl-2-pyridone 
• 3222-47-7 6-methylnicotinic acid 
• 56022-07-2 2,4-dichloro-6-methylnicotinic acid 
• 846576-73-6 2,4-dihydroxy-6-methyl-5-(4-nitro-benzenesulfonyl)-nicotinic acid ethyl ester 

Relevant articles and documents

A 2, 4 - dihydroxy - 6 - methyl-nicotinic acid ethyl ester preparation method (by machine translation)

The invention discloses a 2, 4 - dihydroxy - 6 - methyl-nicotinic acid ethyl ester preparation method, the method is 3 - amino-crotonic acid ethyl ester with malonic acid diethyl ester in ethanol sodium under the action of the condensation and dick graceful esterclaye woods ester gram one after the condensation reaction to produce the product 2, 4 - dihydroxy - 6 - methyl-nicotinic acid ethyl ester. The method of the invention condensation and two-step responds the Claye woods ester gramdick graceful ester condensation reactions are carried out in the same system, significantly shortens the reaction time, greatly reduces the production cost, simple preparation method of the present invention, the reaction system is green, and the reaction conditions are not severe, the obtained product purity is up to 99% or more, and the yield can reach 80% or more, so it is suitable for industrial large-scale production. (by machine translation)