70259-90-4

Basic information

• Product Name: 3-methylidene-1-phenylpyrrolidin-2-one
• CAS NO: 70259-90-4
• Molecular Formula: C₁₁H₁₁NO
• Molecular Weight: 173.2111
• Mol File: 70259-90-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 263.7°C at 760 mmHg
• Flash Point: 113.5°C
• Density: 1.13g/cm³
• Vapor Pressure: 0.0101mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: 3-methylidene-1-phenylpyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methylidene-1-phenylpyrrolidin-2-one(70259-90-4)
• EPA Substance Registry System: 3-methylidene-1-phenylpyrrolidin-2-one(70259-90-4)

Safety Data

• Hazardous Substances Data: 70259-90-4(Hazardous Substances Data)

Upstream product

• 109898-12-6 3-Acetoxymethyl-2-oxo-1-phenyl-pyrrolidine-3-carboxylic acid allyl ester 
• 23421-89-8 2-oxo-1-phenyl-pyrrolidine-3-carboxylic acid ethyl ester 
• 4641-57-0 1-phenylpyrrolidin-2-one 
• 591-50-4 iodobenzene 
• 76220-95-6 3-methylene-2-pyrrolidinone 

Relevant articles and documents

Thiol Reactivity of N-Aryl α-Methylene-γ-lactams: A Reactive Group for Targeted Covalent Inhibitor Design

Kinase activity can be modulated reversibly or irreversibly by the reaction of targeted covalent inhibitors with nucleophilic residues in protein active sites. Herein, we present thiol reactivity studies that support α-methylene-γ-lactams as tunable surro

A General Synthetic Method for α-Methylene Compounds by the Palladium-Catalyzed Decarboxylation-Deacetoxylation of Allyl α-Acetoxymethylcarboxylates Substituted by an Electron-Withdrawing Group at α-Position

Allyl α-acetoxymethylcarboxylates substituted by ester, amide, nitro, cyano, and sulfonyl groups at α-position undergo smooth palladium-catalyzed decarboxylation-deacetoxylation under mild neutral conditions to afford corresponding α-methylene compounds in high yields.