703-12-8

Basic information

• Product Name: 4-BROMO-N-METHYL-BENZENESULFONAMIDE
• Synonyms: 4-BROMO-N-METHYL-BENZENESULFONAMIDE;4-BROMO-N-METHYLBENZENESULPHONAMIDE;N-METHYL 4-BROMOBENZENESULFONAMIDE;p-bromo-n-methyl-benzenesulfonamid;4-Bromo-N-methylbenzenesulphonamide 98%;p-Bromo-N-methylbenzenesulfonamide;4-broMo-N-Methylbenzene-1-sulfonaMide;BenzenesulfonaMide,4-broMo-N-Methyl-
• CAS NO: 703-12-8
• Molecular Formula: C₇H₈BrNO₂S
• Molecular Weight: 250.11
• Product Categories: blocks;Bromides;Sulfonamides;Aryl;Organohalides;Sulfonamide
• Mol File: 703-12-8.mol
• Article Data: 45

Chemical Properties

• Melting Point: 70-72
• Boiling Point: 330.3 °C at 760 mmHg
• Flash Point: 153.6 °C
• Appearance: /
• Density: 1.601 g/cm³
• Vapor Pressure: 0.000167mmHg at 25°C
• Refractive Index: 1.574
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 11.10±0.30(Predicted)
• CAS DataBase Reference: 4-BROMO-N-METHYL-BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-N-METHYL-BENZENESULFONAMIDE(703-12-8)
• EPA Substance Registry System: 4-BROMO-N-METHYL-BENZENESULFONAMIDE(703-12-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 703-12-8(Hazardous Substances Data)

Usage

General Description

4-Bromo-N-methyl-benzenesulfonamide is a chemical compound with the molecular formula C7H8BrNO2S. It is a white to off-white solid that is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 4-BROMO-N-METHYL-BENZENESULFONAMIDE is a derivative of benzenesulfonamide, with a methyl group and a bromide substituent attached to the nitrogen and carbon atoms, respectively. It is also known for its potential use in the treatment of inflammatory and autoimmune diseases due to its inhibitory effects on certain enzymes. 4-Bromo-N-methyl-benzenesulfonamide is often handled and stored with proper protective measures due to its potential hazards, and it is important to follow safety guidelines when working with this chemical.

InChI:InChI=1/C7H8BrNO2S/c1-9-12(10,11)7-4-2-6(8)3-5-7/h2-5,9H,1H3

Upstream product

• 593-51-1 methylamine hydrochloride 
• 98-58-8 4-bromobenzenesulfonyl chloride 
• 86674-11-5 C₇H₇BrN₂O₄S 
• 42111-84-2 C₆H₅BrNO₂S^(1-)*Na⁽¹⁺⁾ 
• 74-88-4 methyl iodide 
• 108-30-5 succinic acid anhydride 
• 701-34-8 4-bromo-benzenesulfonic acid amide 
• 74-89-5 methylamine 
• 67-56-1 methanol 
• 1158827-44-1 methyl N-(4-bromobenzene)sulfonyl-L-serinate 
• 106-53-6 para-bromobenzenethiol 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 

Downstream Products

• 52260-15-8 N-Methyl-(α-carbomethoxybenzyl)-p-brombenzolsulfonamid 
• 56059-54-2 N-Methyl-N-thallium(I)-4-bromphenylsulfonamid 
• 53119-81-6 N-Methyl-(α-phenyl-β-p-toluolsulfonoxyethyl)-p-brombenzolsulfonamid 
• 86674-11-5 C₇H₇BrN₂O₄S 
• 226396-31-2 (4-[N-methylsulfamoyl]phenyl)boronic acid 
• 68502-14-7 C₁₂H₁₁NO₄S 
• 52260-09-0 N-Methyl-N-(α-styryl)-p-brombenzolsulfonamid 
• 731018-65-8 (E)-4-(2-cyclohexyl-1-hydroxymethyl-vinyl)-N-methyl-benzenesulfonamide 
• 867332-77-2 4-bromo-N-methyl-N-(2-morpholin-4-yl-ethyl)-benzenesulfonamide 
• 158425-24-2 N-methyl-N-(4-methoxybenzyl)-4-bromophenylsulfonamide 
• 117795-90-1 4-bromo-N [2 (3-chlorophenyl).2,3-epoxypropyl]-N-methylbenzenesulfonamide 
• 1055994-54-1 4-(5-cyano-1-methyl-1H-pyrrol-2-yl)-N-methylbenzenesulfonamide 
• 1166182-12-2 tert-butyl (4-bromophenyl)sulfonyl(methyl)carbamate 
• 333434-62-1 N-benzyl-4-bromo-N-methylbenzenesulfonamide 

Relevant articles and documents

Copper-catalyzed oxidative methylation of sulfonamides by dicumyl peroxide

A novel and facile copper-catalyzed methylation of sulfonamides was herein demonstrated. The practical transformation took place readily under the oxidative conditions, and N-methyl amides (23 examples) were successfully furnished in high efficiency (up to 90% yields). Dicumyl peroxide was considered to act not only as the oxidant in the system, but also methyl donor for the methylation protocol.

N-Methylation of Amines with Methanol in the Presence of Carbonate Salt Catalyzed by a Metal-Ligand Bifunctional Ruthenium Catalyst [(p-cymene)Ru(2,2′-bpyO)(H2O)]

A ruthenium complex [(p-cymene)Ru(2,2′-bpyO)(H2O)] was found to be a general and efficient catalyst for the N-methylation of amines with methanol in the presence of carbonate salt. Moreover, a series of sensitive substituents, such as nitro, ester, cyano, and vinyl groups, were tolerated under present conditions. It was confirmed that OH units in the ligand are crucial for the catalytic activity. Notably, this research exhibited the potential of metal-ligand bifunctional ruthenium catalysts for the hydrogen autotransfer process.

Method for synthesizing N-methyl sulfonamide in water

The invention discloses a method N - for synthesizing,methylsulfamide in water, by using a transition metal iridium catalyst to catalyze N - methylation reaction. by using a non-toxic and harmless water as a solvent, to avoid using the organic agent; to react only as a byproduct, without an environmental hazard; reaction temperature with respect to the previous strip more mild; and have a wide application prospect; with high selectivity, reaction atomic economy.