703-33-3Relevant articles and documents
KRAS G12C INHIBITORS AND METHODS OF USING THE SAME
-
, (2018/07/15)
Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
KRAS G12C INHIBITORS AND METHODS OF USING THE SAME
-
, (2018/12/04)
Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines
Kaizerman, Jacob A.,Aaron, Wade,An, Songzhu,Austin, Richard,Brown, Matt,Chong, Angela,Huang, Tom,Hungate, Randall,Jiang, Ben,Johnson, Michael G.,Lee, Gary,Lucas, Brian S.,Orf, Jessica,Rong, Minqing,Toteva, Maria M.,Wickramasinghe, Dineli,Xu, Guifen,Ye, Qiuping,Zhong, Wendy,McMinn, Dustin L.
scheme or table, p. 4607 - 4610 (2010/10/02)
Pyridopyridazine antagonists of the hedgehog signaling pathway are described. Designed to optimize our previously described phthalazine smoothened antagonists, a representative compound eliminates a PXR liability while retaining potency and in vitro metab