7031-65-4

Basic information

• Product Name: 2,3-dihydro-1,4-benzodioxin-2-ylmethyl methanesulfonate
• CAS NO: 7031-65-4
• Molecular Formula: C₁₀H₁₂O₅S
• Molecular Weight: 244.2643
• Mol File: 7031-65-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 409.5°C at 760 mmHg
• Flash Point: 201.4°C
• Density: 1.332g/cm³
• Vapor Pressure: 1.53E-06mmHg at 25°C
• Refractive Index: 1.536
• CAS DataBase Reference: 2,3-dihydro-1,4-benzodioxin-2-ylmethyl methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dihydro-1,4-benzodioxin-2-ylmethyl methanesulfonate(7031-65-4)
• EPA Substance Registry System: 2,3-dihydro-1,4-benzodioxin-2-ylmethyl methanesulfonate(7031-65-4)

Safety Data

• Hazardous Substances Data: 7031-65-4(Hazardous Substances Data)

Usage

General Description

2,3-dihydro-1,4-benzodioxin-2-ylmethyl methanesulfonate is a synthetic chemical compound with potential applications in pharmaceuticals and organic synthesis. It is derived from 1,4-benzodioxin, which is a cyclic ether structure consisting of two benzene rings fused to a 1,4-dioxane ring. 2,3-dihydro-1,4-benzodioxin-2-ylmethyl methanesulfonate is often used as a methanesulfonate ester, in which a methyl group is bonded to the sulfur of a methanesulfonic acid molecule. Methanesulfonate esters are commonly used as protecting groups in organic synthesis to block reactive functional groups and prevent unwanted reactions. The specific properties and uses of 2,3-dihydro-1,4-benzodioxin-2-ylmethyl methanesulfonate make it a valuable chemical in the development of pharmaceuticals and other organic compounds.

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 3663-82-9 2-hydroxymethyl-2,3-dihydrobenzo[1,4]dioxin 

Downstream Products

• 73735-21-4 (3-Benzyl-3H-imidazo[4,5-b]pyridin-2-yl)-[1-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-piperidin-4-yl]-amine 
• 76335-54-1 1-[(2,3-dihydro-4H-1,4-benzodioxin)-2-ylmethyl]-4-(4-methoxy-benzoyl)piperidine 
• 1613316-32-7 C₁₇H₁₅BrO₅ 
• 1613316-36-1 C₂₈H₃₁NO₆S₂ 
• 1613316-37-2 C₂₈H₃₁NO₇S 
• 1613316-38-3 C₂₈H₃₁NO₇S 
• 1613315-85-7 C₂₁H₁₈O₅S 
• 1613315-86-8 C₂₁H₁₈O₅S 
• 1613315-88-0 C₂₁H₁₈O₆ 
• 1613315-90-4 C₂₁H₁₈O₆ 
• 1613315-96-0 C₂₀H₁₆O₅S 
• 1613315-98-2 C₂₀H₁₆O₅S 
• 1613316-00-9 C₂₀H₁₆O₆ 
• 1613316-01-0 C₂₀H₁₆O₆ 

Relevant articles and documents

A short entry to enantiopure 2-substituted 1,4-benzodioxanes by efficient resolution methods

(R)-1,4-Benzodioxane-2-carboxilic acid (R)-1 was obtained by resolution of the racemic acid 1 with stoichiometric or nonstoichiometric (+)- dehydroabietylamine (+)-2 in high chemical yield and enantiomeric excess. (S)-1 was isolated from the mother liquors of the crystallisation of (R)-1·(+)-2 and its enantiomeric excess maximised by recrystallisation procedures involving a precipitation under kinetic control or, alternatively, by conversion into the methyl ester followed by a single crystallisation. The different mechanisms of the two S enrichments is well explained by the binary phase diagrams of the acid and of the ester, which show that the former is a racemic compound, whereas the latter a conglomerate. The DSC analyses were extended to 2-hydroxymethyl- and 2-mesyloxymethyl-1,4-benzodioxane, establishing that the alcohol forms a racemic compound, while its mesyl ester a conglomerate. On the basis of these results, different resolution strategies can be designed to obtain useful homochiral 2-substituted 1,4-benzodioxanes coupling the resolution of 1 via diastereomeric salt formation with the enantiomeric enrichments by recrystallisations, preferably of its conglomerate forming derivatives.