70310-30-4

Basic information

• Product Name: 2H-1,4-Benzoxazine,3,4-dihydro-3-phenyl-(9CI)
• Synonyms: 2H-1,4-Benzoxazine,3,4-dihydro-3-phenyl-(9CI);3-Phenyl-3,4-dihydro-2H-benzo[1,4]oxazine
• CAS NO: 70310-30-4
• Molecular Formula: C₁₄H₁₃NO
• Molecular Weight: 211.25912
• Product Categories: PYRIDINE
• Mol File: 70310-30-4.mol
• Article Data: 24

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2H-1,4-Benzoxazine,3,4-dihydro-3-phenyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1,4-Benzoxazine,3,4-dihydro-3-phenyl-(9CI)(70310-30-4)
• EPA Substance Registry System: 2H-1,4-Benzoxazine,3,4-dihydro-3-phenyl-(9CI)(70310-30-4)

Safety Data

• Hazardous Substances Data: 70310-30-4(Hazardous Substances Data)

Upstream product

• 18065-01-5 2-(2-nitrophenoxy)-1-phenyl-1-ethanone 
• 1493-27-2 ortho-nitrofluorobenzene 
• 669694-87-5 2-[(2-phenyl-2-propenyl)oxy]-1-nitrobenzene 
• 19409-26-8 3-phenyl-2H-1,4-benzoxazine 
• 88-75-5 2-hydroxynitrobenzene 
• 70-11-1 α-bromoacetophenone 
• 95-55-6 2-amino-phenol 
• 98-86-2 acetophenone 
• 100-52-7 benzaldehyde 
• 186663-74-1 tert-butyl (2-hydroxyphenyl)carbamate 

Downstream Products

• 22178-50-3 PCM-0102266 
• 123296-57-1 3-Phenyl-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazine-5,6-dione 
• 324817-55-2 4-nitroso-3-phenyl-3,4-dihydro-2H-1,4-benzoxazine 
• 1388154-58-2 ethyl 3,7-dihydro-3-phenyl-7-oxo-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate 
• 1388153-40-9 3,7-dihydro-N-(3,5-dimethyladamant-1-yl)-7-oxo-3-phenyl-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamide 
• 1388154-49-1 diethyl 2-((2,3-dihydro-3-phenylbenzo[b][1,4]oxazin-4-yl)-methylene)malonate 
• 400084-44-8 4-dichloroacetyl-3-phenyl-3,4-dihydro-2H-1,4-benzoxazine 
• 1441005-92-0 (R)-tert-butyl 3-phenyl-3,4-dihydro-2H-1,4-benzoxazine-4-carboxylate 

Relevant articles and documents

Kinetic Resolution by Lithiation: Highly Enantioselective Synthesis of Substituted Dihydrobenzoxazines and Tetrahydroquinoxalines

Kinetic resolution provided a highly enantioselective method to access a range of 3-aryl-3,4-dihydro-2H-1,4-benzoxazines using n-butyllithium and the chiral ligand sparteine. The enantioenrichment remained high on removing the tert-butoxycarbonyl (Boc) protecting group. The intermediate organolithium undergoes ring opening to an enamine. The kinetic resolution was extended to give enantiomerically enriched substituted 1,2,3,4-tetrahydroquinoxalines and was applied to the synthesis of an analogue of the antibiotic levofloxacin that was screened for its activity against the human pathogen Streptococcus pneumoniae.

Hydrogenation or Dehydrogenation of N-Containing Heterocycles Catalyzed by a Single Manganese Complex

A highly chemoselective base-metal catalyzed hydrogenation and acceptorless dehydrogenation of N-heterocycles is presented. A well-defined Mn complex operates at low catalyst loading (as low as 2 mol %) and under mild reaction conditions. The described catalytic system tolerates various functional groups, and the corresponding reduced heterocycles can be obtained in high yields. Experimental studies indicate a metal-ligand cooperative catalysis mechanism.

Electrochemical hydrogenation of a benzannulated pyridine to a dihydropyridine in acidic solution

The electrochemistry of pyridines in acidic solution is dominated by a 'weak acid' reduction on the cyclic voltammetry timescale. Here we show that electrochemical hydrogenation of a benzannulated pyridine, phenanthridine (1), to the biomimetic hydride do