70336-83-3

Basic information

• Product Name: 4-AMino-1-benzyl-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid ethyl ester
• Synonyms: 4-AMino-1-benzyl-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid ethyl ester;ethyl 4-amino-1-benzyl-1,2,5,6-tetrahydropyridine-3-carboxylate
• CAS NO: 70336-83-3
• Molecular Formula: C₁₅H₂₀N₂O₂
• Molecular Weight: 260.3315
• Mol File: 70336-83-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 190 °C(Press: 0.4 Torr)
• Appearance: /
• Density: 1.147±0.06 g/cm3(Predicted)
• PKA: 6.43±0.60(Predicted)
• CAS DataBase Reference: 4-AMino-1-benzyl-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMino-1-benzyl-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid ethyl ester(70336-83-3)
• EPA Substance Registry System: 4-AMino-1-benzyl-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid ethyl ester(70336-83-3)

Safety Data

• Hazardous Substances Data: 70336-83-3(Hazardous Substances Data)

Upstream product

• 41276-30-6 C₉H₁₄O₃NC₆H₅ 
• 1454-53-1 ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride 

Downstream Products

• 892863-69-3 ethyl 4-amino-1-benzyl-3-piperidinecarboxylate 

Relevant articles and documents

Development of Novel Anticancer Agents with a Scaffold of Tetrahydropyrido[4,3- d]pyrimidine-2,4-dione

ONC201 is a small molecular anticancer agent currently in multiple Phase II clinical trials. Based on the pharmacophore of ONC201, a series of small molecular compounds with a core structure of tetrahydropyrido[4,3-d]pyrimidine-2,4-dione were designed and synthesized. Preliminary mechanism studies of these compounds indicated that they can inhibit the phosphorylation of AKT and ERK, induce the dephosphorylation of Foxo3a, and promote the expression of TRAIL and the enhancement of activating transcription factor 4 (ATF4) in PC-3 cells. Structure-activity relationship (SAR) studies indicated that modifications of the substituted groups on the core structure can significantly improve the cellular activities of these compounds. The most potent compounds are over 100 times more potent than ONC201 in inhibition of cell growth in a panel of different types of human cancer cell lines.