70343-13-4

Basic information

• Product Name: 7-Methyl-5-Nitroisatin
• Synonyms: 7-Methyl-5-Nitroisatin;5-Nitro-7-Methylisatin;7-Methyl-5-nitroindoline-2,3-dione
• CAS NO: 70343-13-4
• Molecular Formula: C₉H₆N₂O₄
• Molecular Weight: 206.15494
• Mol File: 70343-13-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 7-Methyl-5-Nitroisatin(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Methyl-5-Nitroisatin(70343-13-4)
• EPA Substance Registry System: 7-Methyl-5-Nitroisatin(70343-13-4)

Safety Data

• Hazardous Substances Data: 70343-13-4(Hazardous Substances Data)

Usage

General Description

7-Methyl-5-Nitroisatin is a chemical compound with a molecular formula C9H6N2O3. It is a yellowish crystalline solid that is commonly used as a fluorescent dye in biological and medical applications. 7-Methyl-5-Nitroisatin is also used in the synthesis of pharmaceuticals and organic compounds. It has been studied for its potential anticancer and antimicrobial properties. The compound is considered to be of low toxicity and is not considered to be carcinogenic. It has a melting point of 185-187°C and is stable under normal conditions of use and storage. Overall, 7-Methyl-5-Nitroisatin is a versatile and valuable chemical with a range of applications in various scientific and industrial fields.

Upstream product

• 1127-59-9 7-methyl-1H-indole-2,3-dione 
• 95-53-4 o-toluidine 
• 99-52-5 2-methyl-4-nitro-benzenamine 

Downstream Products

• 70343-14-5 2-amino-3-methyl-5-nitrobenzoic acid 
• 90414-59-8 2-Iodo-3-methyl-5-nitrobenzoic acid 
• 908597-08-0 methyl 2-iodo-3-methyl-5-nitrobenzoate 
• 70343-15-6 2,5-dinitro-3-methylbenzoic acid 
• 65321-68-8 2,5-dinitro-3-methylaniline 

Relevant articles and documents

SPIRO[CYCLOPENTANE-1,3'-INDOLIN]-2'-ONE DERIVATIVES AS BROMODOMAIN INHIBITORS

The present invention provides spiro[cyclopentaneane-1,3'-indolin]-2'-one derivatives of formula (I), which are therapeutically useful, more particularly as bromodomain inhibitors. (I) wherein Cy, R1, R2, L and 'm' have the meaning given in the specification, and pharmaceutically acceptable salts or pharmaceutically acceptable stereoisomers thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use as bromodomain inhibitors in the treatment and prevention of the associated diseases or disorders. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the spiro[cyclopentane-1,3'-indolin]-2'-one derivatives of formula (I), together with a pharmaceutically acceptable carrier, diluent or excipient therefore.

The synthesis and resolution of 2,2′-, 4,4′-, and 6,6′-substituted chiral biphenyl derivatives for application in the preparation of chiral materials

Various routes were examined for the synthesis of chiral biphenyl species that are substituted at the 2,2′, 4,4′ and 6,6′ positions. Because the biaryl bond is tetrasubstituted, many coupling reactions were not suitable. The most reliable coupling reaction proved to be the Ullmann, which gave the desired product in 82% yield. The products were required as the starting point for the preparation of chiral materials using these as the monomer. For this reason, a route was required that produced large quantities of both enantiomers. The two enantiomers were resolved at the penultimate step by the use of chiral HPLC. A complicating feature proved to be the necessity to have a reactive group at the 4,4′ positions, which would permit polymerization though this point. Ultimately, we employed an Ullmann coupling on a dibrominated arene, which occurred selectively at the more hindered bromine by virtue of the directing effect of an ortho ester substituent.