70345-38-9

Basic information

• Product Name: 5-Pyrimidinol, 4,6-dimethyl- (6CI,9CI)
• Synonyms: 5-Pyrimidinol, 4,6-dimethyl- (6CI,9CI);5-Pyrimidinol, 4,6-dimethyl;4,6-Dimethyl-5-pyrimidinol;4,6-DiMethylpyriMidin-5-ol;5-Hydroxy-4,6-dimethylpyrimidine
• CAS NO: 70345-38-9
• Molecular Formula: C₆H₈N₂O
• Molecular Weight: 124.14052
• Product Categories: PYRIMIDINE
• Mol File: 70345-38-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 138-139 °C
• Boiling Point: 237.1 °C at 760 mmHg
• Flash Point: 97.2 °C
• Appearance: /
• Density: 1.161g/cm³
• Vapor Pressure: 0.0297mmHg at 25°C
• Refractive Index: 1.548
• Storage Temp.: 2-8°C
• PKA: 7.29±0.20(Predicted)
• CAS DataBase Reference: 5-Pyrimidinol, 4,6-dimethyl- (6CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinol, 4,6-dimethyl- (6CI,9CI)(70345-38-9)
• EPA Substance Registry System: 5-Pyrimidinol, 4,6-dimethyl- (6CI,9CI)(70345-38-9)

Safety Data

• Hazardous Substances Data: 70345-38-9(Hazardous Substances Data)

Usage

General Description

5-Pyrimidinol, 4,6-dimethyl- (6CI,9CI) is a chemical compound with the molecular formula C6H8N2O. It is a derivative of pyrimidine, which is a heterocyclic organic compound. 5-Pyrimidinol, 4,6-dimethyl- is a colorless, crystalline solid that is used in the synthesis of pharmaceuticals and agricultural chemicals. It has potential applications as a building block in the production of medications and compounds used in the agricultural industry. This chemical is also known by its Chemical Abstracts Service (CAS) number 21191-52-4. Overall, it is an important compound in the field of organic chemistry with various potential uses in the manufacturing of different products.

InChI:InChI=1/C6H8N2O/c1-4-6(9)5(2)8-3-7-4/h3,9H,1-2H3

Upstream product

• 1694-29-7 3-chloropentane-2,4-dione 
• 23012-19-3 4-methyl-5-acetyloxazole 

Downstream Products

• 80353-68-0 4,6-Bis-((E)-styryl)-pyrimidin-5-ol 
• 791539-01-0 4-Methyl-6-((E)-styryl)-pyrimidin-5-ol 
• 80353-65-7 4-[(E)-2-(4-Dimethylamino-phenyl)-vinyl]-6-methyl-pyrimidin-5-ol 
• 80353-69-1 4,6-Bis-[(E)-2-(4-dimethylamino-phenyl)-vinyl]-pyrimidin-5-ol 
• 88070-37-5 4,6-dimethyl-5-hydroxypyrimidine-1-oxide 
• 88745-75-9 4-dimethylaminoethyl-5-hydroxy-6-methylpyrimidine 1-oxide 

Relevant articles and documents

6-Amino-2,4,5-trimethylpyridin-3-ol and 2-amino-4,6-dimethylpyrimidin-5-ol derivatives as selective fibroblast growth factor receptor 4 inhibitors: design, synthesis, molecular docking, and anti-hepatocellular carcinoma efficacy evaluation

A novel series of aminotrimethylpyridinol and aminodimethylpyrimidinol derivatives were designed and synthesised for FGFR4 inhibitors. Structure-activity relationship on the FGFR4 inhibitory activity of the new compounds was clearly elucidated by an intensive molecular docking study. Anti-cancer activity of the compounds was evaluated using hepatocellular carcinoma (HCC) cell lines and a chick chorioallantoic membrane (CAM) tumour model. Compound 6O showed FGFR4 inhibitory activity over FGFR1 ? 3. Compared to the positive control BLU9931, compound 6O exhibited at least 8 times higher FGFR4 selectivity. Strong anti-proliferative activity of compound 6O was observed against Hep3B, an HCC cell line which was a much more sensitive cell line to BLU9931. In vivo anti-tumour activity of compound 6O against Hep3B-xenografted CAM tumour model was almost similar to BLU9931. Overall, compound 6O, a novel derivative of aminodimethylpyrimidinol, was a selective FGFR4 kinase inhibitor blocking HCC tumour growth.