70374-37-7

Basic information

• Product Name: Methyl 5-chloro-3-chlorosulfonyl-2-thiophene carboxylate
• Synonyms: Albb-008915;2-Thiophenecarboxylicacid, 5-chloro-3-[(MethylaMino)sulfonyl]-, Methyl ester;5-chloro-3-(methylsulfamoyl)-2-thiophenecarboxylic acid methyl ester;5-chloro-3-(methylsulfamoyl)thiophene-2-carboxylic acid methyl ester;methyl 5-chloro-3-(methylsulfamoyl)thiophene-2-carboxylate;5-Chloro-3-(N-methylsulfamoyl)-thiophene-2-carboxylic acid methy;METHYL-S-CHLORO-3-(N-THETHYLSULLUMOYL)-THIOPHENC-2-CARHOXYLIC OR5-CHLBRO-3-(N-MUTHYLSULFAMOYL ESTER;5-chloro-3-(n-methylsulfamoyl)-thiophene-2-carboxylic acid methyl ester
• CAS NO: 70374-37-7
• Molecular Formula: C7H8ClNO4S2
• Molecular Weight: 269.73
• EINECS: 1308068-626-2
• Product Categories: APIs Intermediate
• Mol File: 70374-37-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 424.6 °C at 760 mmHg
• Flash Point: 210.6 °C
• Appearance: /
• Density: 1.503 g/cm³
• Vapor Pressure: 2.04E-07mmHg at 25°C
• Refractive Index: 1.559
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
• PKA: 10.29±0.50(Predicted)
• CAS DataBase Reference: Methyl 5-chloro-3-chlorosulfonyl-2-thiophene carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 5-chloro-3-chlorosulfonyl-2-thiophene carboxylate(70374-37-7)
• EPA Substance Registry System: Methyl 5-chloro-3-chlorosulfonyl-2-thiophene carboxylate(70374-37-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 70374-37-7(Hazardous Substances Data)

Usage

General Description

"Methyl 5-chloro-3-chlorosulfonyl-2-thiophene carboxylate" is a chemical compound that falls under the category of organosulfur compounds. Specifically, it is a thiophene compound, a class that includes various biologically active compounds and that is significant in the field of pharmaceuticals. The "3-chlorosulfonyl" and "5-chloro" parts of its name indicate the presence of chlorine, while "methyl" and "carboxylate" suggest the presence of carbon-oxygen groups. The precise structure and properties of this compound, including its reactivity, stability, polarity, toxicity, and possible applications in research or industry, would depend on further details not specified in the name.

InChI:InChI=1/C7H8ClNO4S2/c1-9-15(11,12)4-3-5(8)14-6(4)7(10)13-2/h3,9H,1-2H3

Upstream product

• 67-56-1 methanol 

Relevant articles and documents

Synthesis method of lornoxicam intermediate 5-chloro-3-methylsulfonamide thiophene-2-carboxylic acid methyl ester

The invention belongs to the technical field of medicine synthesis, and particularly relates to a synthetic method of a lornoxicam intermediate 5-chloro-3-methyl sulfonamide thiophene-2-carboxylic acid methyl ester. The method comprises the following steps: by taking 5-chloro-3-methyl sulfonamide thiophene-2-carboxylic acid as an initial raw material, dichloromethane as a solvent, N,N-dimethylformamide as a catalyst and thionyl chloride as a chlorination reagent, reacting to generate an acyl chloride active intermediate, then adding triethylamine and methanol, and reacting to generate the 5-chloro-3-methyl sulfonamide thiophene-2-carboxylic acid methyl ester. According to the method, thionyl chloride is used as the chlorination reagent, so that the use of phosphorus pentachloride which is a phosphorus-containing reagent in the traditional process is avoided, and the process is more environment-friendly; meanwhile, dichloromethane is used as a solvent instead of high-toxicity chloroform, so that the pollution of the process to the environment is further reduced.