70380-67-5

Basic information

• Product Name: 5-(2-FURYL)-1,3-OXAZOLE
• Synonyms: 5-(2-FURYL)-1,3-OXAZOLE;5-Fur-2-yl-1,3-oxazole;2-(1,3-Oxazol-5-yl)furan;5-(Furan-2-yl)oxazole
• CAS NO: 70380-67-5
• Molecular Formula: C₇H₅NO₂
• Molecular Weight: 135.12
• Mol File: 70380-67-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 102 °C
• Flash Point: 96.5 °C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 0.122mmHg at 25°C
• Refractive Index: 1.502
• PKA: 0.86±0.10(Predicted)
• CAS DataBase Reference: 5-(2-FURYL)-1,3-OXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-FURYL)-1,3-OXAZOLE(70380-67-5)
• EPA Substance Registry System: 5-(2-FURYL)-1,3-OXAZOLE(70380-67-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 70380-67-5(Hazardous Substances Data)

Usage

General Description

5-(2-FURYL)-1,3-OXAZOLE is a chemical compound with the molecular formula C7H6NO2. It is a heterocyclic compound containing a furan ring fused to an oxazole ring. 5-(2-FURYL)-1,3-OXAZOLE is commonly used in the food industry as a flavoring agent, providing a characteristic nutty and slightly sweet flavor to foods and beverages. It is also used in the fragrance industry to add a sweet and floral note to perfumes and other scented products. In addition, 5-(2-FURYL)-1,3-OXAZOLE has been studied for its potential biological activities, including its antimicrobial and antioxidant properties.

InChI:InChI=1/C7H5NO2/c1-2-6(9-3-1)7-4-8-5-10-7/h1-5H

Upstream product

• 98-01-1 furfural 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 87022-42-2 1-(isocyanomethyl)-1H-benzo[d][1,2,3]triazole 
• 195711-05-8 1-(isocyanomethyloxy)benzotriazole 
• 95-54-5 1,2-diamino-benzene 
• 98-00-0 (2-furyl)methyl alcohol 

Downstream Products

• 1370422-78-8 5-(2-furanyl)-2-{(4-methoxyphenyl)ethynyl}oxazole 

Relevant articles and documents

Synthesis of furan derivatives. LXXXV. Condensation of heteroaromatic aldehydes with tosylmethyl isocyanide

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A One-Pot Tandem Approach for the Synthesis of 5-(Het)aryloxazoles from Substituted (Het)aryl Methyl Alcohols and Benzyl Bromides

A new modified van Leusen strategy has been developed for the synthesis of biologically significant 5-substituted oxazoles by the reaction of (het)aryl methyl alcohols or benzyl bromides as precursors with tosylmethylisocyanide (TosMIC) under basic conditions. This method is efficient, takes place under mild reaction conditions, and is tolerant of various functional groups with high yield.

Reactions between weinreb amides and 2-magnesiated oxazoles: A simple and efficient preparation of 2-acyl oxazoles

(Chemical Equation Presented) Treatment of oxazole or 5-aryl oxazoles with i-PrMgCl smoothly generates the corresponding 2-Grignard reagents, which react with Weinreb amides to provide exclusively 2-acyl oxazole products.